Reactome | MCL1 [cytosol]

MCL1 [cytosol]

Stable Identifier

R-HSA-5661490

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Induced myeloid leukemia cell differentiation protein Mcl-1, MCL1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y478 PRKAB1

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External Reference Information

External Reference

UniProt:Q07820 MCL1

Gene Names

MCL1, BCL2L3

Chain

chain:1-350

Reference Genes

BioGPS Gene:4170 MCL1

COSMIC (genes):MCL1 MCL1

CTD Gene:4170 MCL1

dbSNP Gene:4170 MCL1

ENSEMBL:ENSG00000143384 MCL1

HGNC:6943 MCL1

Monarch:4170 MCL1

NCBI Gene:4170 MCL1

OMIM:159552 MCL1

UCSC:Q07820 MCL1

Reference Transcript

Other Identifiers

11715482_a_at

11715483_s_at

11715484_a_at

11715485_a_at

11715486_x_at

11715487_a_at

16692772

16692775

200796_PM_s_at

200796_s_at

200797_PM_s_at

200797_s_at

200798_PM_x_at

200798_x_at

241722_PM_x_at

241722_x_at

2434439

2434441

2434448

2434449

2434450

2434451

2434452

2434453

2434454

2434455

2434456

2434457

2434458

2434459

2434460

2434461

2434462

2434463

2434464

2434465

2434466

2434467

2434468

2434469

2434470

2434471

277_at

33146_at

4170

574406

62246_at

7919743

7919751

A_24_P319635

A_24_P336754

A_24_P336759

A_33_P3275412

A_33_P3336148

GE82631

GE85366

GE86943

GO:0001709

GO:0001836

GO:0005215

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0006915

GO:0006950

GO:0006974

GO:0007005

GO:0008053

GO:0008320

GO:0008630

GO:0010507

GO:0012501

GO:0015267

GO:0016020

GO:0019725

GO:0030154

GO:0034097

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0046982

GO:0051400

GO:0051434

GO:0055085

GO:0071806

GO:0097136

GO:0097192

GO:1903378

GO:2000811

GO:2001233

GO:2001240

HMNXSV003005695

HMNXSV003019388

HMNXSV003041006

Hs.160999.1.A1_3p_at

Hs.86386.0.S1_3p_a_at

Hs.86386.0.S3_3p_a_at

ILMN_1705904

ILMN_1756806

ILMN_1803988

L08246_at

PH_hs_0004861

TC01003204.hg

TC01003205.hg

TC01005816.hg

g11386164_3p_a_at

Participates

as a member of

STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)

as an output of

NPM1-ALK- and TYK2-dependent MCL1 gene expression (Homo sapiens)

Cross References

Guide to Pharmacology - Targets

2847

OpenTargets

ENSG00000143384

ENSEMBL

ENSP00000309973, ENST00000307940, ENSP00000358022, ENSP00000502859, ENST00000678770, ENST00000369026

ZINC - Substances

MCL1_HUMAN

ZINC - Biogenic

MCL1_HUMAN

ZINC target

Q07820

PRO

Q07820

PDB

5KU9, 3WIX, 6UDT, 6QZ8, 6QYN, 3D7V, 8G3Y, 6QZ5, 4OQ5, 6QYL, 4WMW, 5IEZ, 6FS2, 6YBG, 6STJ, 4OQ6, 4BPI, 4WMU, 7NB4, 5IF4, 6BW2, 6UAB, 6QGD, 3KJ1, 3IO9, 6YBK, 6QFQ, 5VKC, 2NLA, 8G3W, 8G3X, 2PQK, 6QB4, 6OVC, 2NL9, 6MBE, 6QYP, 6QYO, 6VBX, 6UDV, 4BPJ, 6QFI, 6OQC, 4WMR, 3WIY, 8EKX, 5MEV, 6FS1, 6U67, 4WMV, 4ZBF, 3KZ0, 6U6F, 6B4L, 5W89, 6B4U, 7NB7, 6QFC, 8G3T, 6MBD, 4HW3, 6QB3, 5FC4, 8H7B, 2MHS, 6UDY, 6QZ7, 6UA3, 8QSO, 6P3P, 6UDU, 4WMS, 6OQB, 6U65, 5C6H, 8EL0, 6O6F, 6FS0, 7XGE, 6YBJ, 8SVY, 6BW8, 4WMX, 5MES, 6QZB, 6QFM, 8T6F, 6YBL, 8AV9, 5UUM, 8G3U, 4HW4, 8G3S, 6U64, 5FDO, 3KJ2, 6QB6, 4WGI, 6OQN, 4WMT, 6QZ6, 6UDI, 6ZIE, 6UDX, 8EL1, 6O4U, 6OQD, 6QYK, 6NE5, 6QXJ, 6O6G, 3PK1, 3KJ0, 6UD2, 8IQM, 4ZBI, 3TWU, 8VJP, 2KBW, 4HW2, 5LOF, 3MK8, 5W8F, 5C3F, 6U63, 5VX2, 5JSB, 5FDR

ZINC - Investigational

MCL1_HUMAN

ZINC - Metabolites

MCL1_HUMAN

HPA

ENSG00000143384-MCL1

Pharos - Targets

Q07820

ZINC - Predictions - Purchasable

MCL1_HUMAN

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.96	19
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.948	19
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.883	10
UniProt:Q13794 PMAIP1	2	PMAIP1 [mitochondrial outer membrane] (R-HSA-140218) PMAIP1 [cytosol] (R-HSA-140215)	0.845	6
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [secretory granule lumen] (R-HSA-6801481) HUWE1 [cytosol] (R-HSA-975983)	0.841	11
UniProt:Q9BXH1 BBC3	2	BBC3 [mitochondrial outer membrane] (R-HSA-140222) BBC3 [cytosol] (R-HSA-140220)	0.759	5
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.702	3
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.679	10
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q9UNK0 STX8			0.556	3
UniProt:Q9H3M0 KCNF1	1	KCNF1 [plasma membrane] (R-HSA-977450)	0.556	3
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:P25101 EDNRA	1	EDNRA [plasma membrane] (R-HSA-388549)	0.527	2
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.527	2
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.527	2
UniProt:O60518 RNBP6			0.527	2
IntAct:EBI-4399559 UBIQ			0.524	4
UniProt:Q91AU0 Q91AU0			0.524	2
UniProt:Q9BXH1-2 BBC3			0.524	2
UniProt:Q7L3V2 BOP			0.499	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.463	3
UniProt:P49817 Cav1	6	caveolin-1 [lipid droplet] (R-MMU-163603) Cav1 [early endosome membrane] (R-MMU-5368451) Cav1 [endocytic vesicle membrane] (R-MMU-535009) Cav1 [lipid droplet] (R-MMU-163510) Cav1 [plasma membrane] (R-MMU-534994) Cav1 [Golgi membrane] (R-MMU-204504)	0.463	3
UniProt:Q9Q2G4 Q9Q2G4			0.462	2

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