DCXR tetramer reduces L-xylulose to xylitol

Stable Identifier
R-HSA-5661240
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
L-xylulose + NADPH + H+ <=> xylitol + NADP+
ReviewStatus
5/5
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DCXR tetramer reduces L-xylulose to xylitol
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L-xylulose reductase (DCXR, also known as dicarbonyl/L-xylulose reductase) catalyzes the reversible NADPH dependent reduction of cytosolic L-xylulose to xylitol (Nakagawa et al. 2002). The enzyme is a tetramer (El Kabbani et al.2004) and may be associated with the plasma membrane (Boue et al. 1996). Mutations that inactivate DCXR are associated with essential pentosuria (Pierce et al. 2011; Wang & van Eys 1970).
Literature References
PubMed ID Title Journal Year
4392213 The enzymatic defect in essential pentosuria

Wang, YM, Van Eys, J

N. Engl. J. Med. 1970
8722620 Surface localization of P34H an epididymal protein, during maturation, capacitation, and acrosome reaction of human spermatozoa

Boué, F, Blais, J, Sullivan, R

Biol. Reprod. 1996
22042873 Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria

Pierce, SB, Spurrell, CH, Mandell, JB, Lee, MK, Zeligson, S, Bereman, MS, Stray, SM, Fokstuen, S, Maccoss, MJ, Levy-Lahad, E, King, MC, Motulsky, AG

Proc. Natl. Acad. Sci. U.S.A. 2011
11882650 Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney

Nakagawa, J, Ishikura, S, Asami, J, Isaji, T, Usami, N, Hara, A, Sakurai, T, Tsuritani, K, Oda, K, Takahashi, M, Yoshimoto, M, Otsuka, N, Kitamura, K

J. Biol. Chem. 2002
15103634 Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis

El-Kabbani, O, Ishikura, S, Darmanin, C, Carbone, V, Chung, RP, Usami, N, Hara, A

Proteins 2004
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Catalyst Activity

L-xylulose reductase (NADPH) activity of DCXR tetramer [plasma membrane]

Physical Entity
DCXR tetramer [plasma membrane] (Homo sapiens)
Activity
L-xylulose reductase (NADPH) activity (GO:0050038)
Orthologous Events
DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)
DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)
DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)
DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)
DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)
DCXR tetramer reduces L-xylulose to xylitol (Gallus gallus)
DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)
DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)
DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)
DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2015-08-14)
Reviewed
Jassal, B  (2015-08-14)
Created
D'Eustachio, P  (2015-01-10)
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