L-xylulose reductase (DCXR, also known as dicarbonyl/L-xylulose reductase) catalyzes the reversible NADPH dependent reduction of cytosolic L-xylulose to xylitol (Nakagawa et al. 2002). The enzyme is a tetramer (El Kabbani et al.2004) and may be associated with the plasma membrane (Boue et al. 1996). Mutations that inactivate DCXR are associated with essential pentosuria (Pierce et al. 2011; Wang & van Eys 1970).
Van Eys, J, Wang, YM
Boué, F, Sullivan, R, Blais, J
King, MC, Fokstuen, S, Lee, MK, Levy-Lahad, E, Motulsky, AG, Maccoss, MJ, Stray, SM, Bereman, MS, Spurrell, CH, Zeligson, S, Pierce, SB, Mandell, JB
Asami, J, Hara, A, Tsuritani, K, Kitamura, K, Takahashi, M, Oda, K, Yoshimoto, M, Isaji, T, Otsuka, N, Sakurai, T, Usami, N, Ishikura, S, Nakagawa, J
Hara, A, Carbone, V, El-Kabbani, O, Darmanin, C, Chung, RP, Usami, N, Ishikura, S
L-xylulose reductase (NADP+) activity of DCXR tetramer [plasma membrane]
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