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MT1A binds arsenic
Stable Identifier
R-HSA-5661230
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Response to metal ions (Homo sapiens)
Metallothioneins bind metals (Homo sapiens)
MT1A binds arsenic (Homo sapiens)
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Metallothionein MT1A binds 6 atoms of arsenic(III), 3 atoms at the N-terminal beta domain and 3 atoms at the C-terminal alpha domain (Ngu and Stillman 2006, Irvine et al. 2013). Each arsenic atom binds 3 cysteine thiols (Ngu and Stillman 2006, Irvine et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
16984198
Arsenic binding to human metallothionein
Stillman, MJ
,
Ngu, TT
J. Am. Chem. Soc.
2006
23523794
Cysteine accessibility during As3+ metalation of the ?- and ?-domains of recombinant human MT1a
Stillman, MJ
,
Summers, KL
,
Irvine, GW
Biochem. Biophys. Res. Commun.
2013
Participants
Input
x 6
As3+ [cytosol]
MT1A [cytosol]
(Homo sapiens)
Output
MT1A:6As3+ [cytosol]
(Homo sapiens)
Participates
as an event of
Metallothioneins bind metals (Homo sapiens)
Orthologous Events
MT1A binds arsenic (Bos taurus)
MT1A binds arsenic (Canis familiaris)
MT1A binds arsenic (Danio rerio)
MT1A binds arsenic (Gallus gallus)
MT1A binds arsenic (Mus musculus)
MT1A binds arsenic (Rattus norvegicus)
MT1A binds arsenic (Sus scrofa)
Authored
May, B (2015-01-07)
Reviewed
Atrian, S (2015-09-19)
Created
May, B (2015-01-10)
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