Reactome | MT1A binds cadmium

MT1A binds cadmium

Stable Identifier

R-HSA-5661219

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MT1A binds 7 atoms of cadmium(II), 3 atoms at the N-terminal beta domain and 4 atoms at the C-terminal alpha domain (Rigby Duncan et al. 2008, Sunderland and Stillman 2008, Sutherland et al. 2012). A fifth cadmium atom bound to the alpha domain may be an intermediate formed during metal exchange (Rigby Duncan et al. 2008). Binding of cadmium is non-cooperative (Rigby Duncan and Stillman 2007, Sunderland and Stillman 2008). As inferred from mouse Mt1, MT1A may show less preference for zinc compared with cadmium and may therefore serve more than other metallothionein isoforms to detoxify cadmium.

Literature References

PubMed ID	Title	Journal	Year
18533113	Noncooperative cadmium(II) binding to human metallothionein 1a Stillman, MJ, Sutherland, DE	Biochem. Biophys. Res. Commun.	2008
18429853	Metal exchange in metallothioneins: a novel structurally significant Cd(5) species in the alpha domain of human metallothionein 1a Stillman, MJ, Kirby, CW, Rigby Duncan, KE	FEBS J.	2008
22982309	Modeling the Zn(2+) and Cd(2+) metalation mechanism in mammalian metallothionein 1a Stillman, MJ, Summers, KL, Sutherland, DE	Biochem. Biophys. Res. Commun.	2012
22242602	Single domain metallothioneins: supermetalation of human MT 1a Stillman, MJ, Willans, MJ, Sutherland, DE	J. Am. Chem. Soc.	2012
17388808	Evidence for noncooperative metal binding to the alpha domain of human metallothionein Stillman, MJ, Rigby Duncan, KE	FEBS J.	2007