MT1A binds zinc

Stable Identifier
R-HSA-5661217
Type
Reaction
Species
Homo sapiens
Compartment
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The MT1A metallothionein binds 7 zinc(II) atoms, 3 at the N-terminal beta domain and 4 at the C-terminal alpha domain (Sunderland et al. 2012). Binding is non-cooperative (Sunderland et al. 2012) and occurs via thiolate bonds between zinc and cysteine residues of the protein. MT1A binds 5 atoms of zinc before clustering of the zinc occurs (Summers et al. 2013). The 2 remaining zinc atoms bind MT1A with significantly less affinity (Summers et al. 2013).

Literature References
PubMed ID Title Journal Year
23506369 Single-domain metallothioneins: evidence of the onset of clustered metal binding domains in Zn-rhMT 1a

Stillman, MJ, Summers, KL, Sutherland, DE

Biochemistry 2013
22823575 Noncooperative metalation of metallothionein 1a and its isolated domains with zinc

Stillman, MJ, Summers, KL, Sutherland, DE

Biochemistry 2012
22982309 Modeling the Zn(2+) and Cd(2+) metalation mechanism in mammalian metallothionein 1a

Stillman, MJ, Summers, KL, Sutherland, DE

Biochem. Biophys. Res. Commun. 2012
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