Reactome | MT1A binds zinc

MT1A binds zinc

Stable Identifier

R-HSA-5661217

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The MT1A metallothionein binds 7 zinc(II) atoms, 3 at the N-terminal beta domain and 4 at the C-terminal alpha domain (Sunderland et al. 2012). Binding is non-cooperative (Sunderland et al. 2012) and occurs via thiolate bonds between zinc and cysteine residues of the protein. MT1A binds 5 atoms of zinc before clustering of the zinc occurs (Summers et al. 2013). The 2 remaining zinc atoms bind MT1A with significantly less affinity (Summers et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23506369	Single-domain metallothioneins: evidence of the onset of clustered metal binding domains in Zn-rhMT 1a Stillman, MJ, Summers, KL, Sutherland, DE	Biochemistry	2013
22823575	Noncooperative metalation of metallothionein 1a and its isolated domains with zinc Stillman, MJ, Summers, KL, Sutherland, DE	Biochemistry	2012
22982309	Modeling the Zn(2+) and Cd(2+) metalation mechanism in mammalian metallothionein 1a Stillman, MJ, Summers, KL, Sutherland, DE	Biochem. Biophys. Res. Commun.	2012