MT1A binds zinc

Stable Identifier
R-HSA-5661217
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The MT1A metallothionein binds 7 zinc(II) atoms, 3 at the N-terminal beta domain and 4 at the C-terminal alpha domain (Sunderland et al. 2012). Binding is non-cooperative (Sunderland et al. 2012) and occurs via thiolate bonds between zinc and cysteine residues of the protein. MT1A binds 5 atoms of zinc before clustering of the zinc occurs (Summers et al. 2013). The 2 remaining zinc atoms bind MT1A with significantly less affinity (Summers et al. 2013).

Literature References
PubMed ID Title Journal Year
22823575 Noncooperative metalation of metallothionein 1a and its isolated domains with zinc

Sutherland, DE, Summers, KL, Stillman, MJ

Biochemistry 2012
23506369 Single-domain metallothioneins: evidence of the onset of clustered metal binding domains in Zn-rhMT 1a

Summers, KL, Sutherland, DE, Stillman, MJ

Biochemistry 2013
22982309 Modeling the Zn(2+) and Cd(2+) metalation mechanism in mammalian metallothionein 1a

Sutherland, DE, Summers, KL, Stillman, MJ

Biochem. Biophys. Res. Commun. 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed