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SLCO1B3 I562* [plasma membrane]
Stable Identifier
R-HSA-5661201
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OATP-8, Solute carrier organic anion transporter family member 1B3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) (Homo sapiens)
Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)
SLCO1B3 I562* [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPD5 SLCO1B3
Gene Names
SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8
Chain
chain:1-702
Reference Genes
BioGPS Gene:28234 SLCO1B3
COSMIC (genes):SLCO1B3 SLCO1B3
CTD Gene:28234 SLCO1B3
dbSNP Gene:28234 SLCO1B3
ENSEMBL:ENSG00000111700 SLCO1B3
HGNC:10961 SLCO1B3
KEGG:hsa:28234 SLCO1B3
Monarch:28234 SLCO1B3
NCBI Gene:28234 SLCO1B3
OMIM:605495 SLCO1B3
UCSC:Q9NPD5 SLCO1B3
Reference Transcript
RefSeq:NM_019844.3 SLCO1B3
Other Identifiers
11732569_at
16749036
206354_PM_at
206354_at
28234
3407630
3407631
3407632
3407633
3407639
3407640
3407641
3407643
3407644
3407645
3407646
3407649
3407650
3407651
3407652
3407653
3407655
3407656
3407657
3407660
3407663
3407664
3407665
3407666
3407667
3407668
3407686
3407689
3407690
3407693
7954330
A_14_P102835
A_14_P108697
A_14_P133603
A_23_P105475
A_33_P3364089
GE82482
GO:0004867
GO:0005215
GO:0005515
GO:0005886
GO:0006805
GO:0006811
GO:0006869
GO:0008514
GO:0009925
GO:0015125
GO:0015347
GO:0015711
GO:0015721
GO:0016020
GO:0016323
GO:0022857
GO:0042167
GO:0043252
GO:0055085
GO:0098772
HMNXSV003006405
ILMN_1687319
PH_hs_0030139
TC12002282.hg
g9790232_3p_at
Other forms of this molecule
SLCO1B3 [plasma membrane]
Modified Residues
Name
Nonsense mutation at L-isoleucine 562
Coordinate
562
PsiMod
L-isoleucine removal [MOD:01640]
A protein modification that effectively removes or replaces an L-isoleucine.
Disease
Name
Identifier
Synonyms
bilirubin metabolic disorder
DOID:2741
hyperbilirubinemia, hereditary hyperbilirubinemia
Cross References
ZINC - World Drugs
SO1B3_HUMAN
Guide to Pharmacology - Targets
1221
ENSEMBL
ENST00000261196
,
ENSP00000370956
,
ENST00000381545
,
ENSP00000261196
OpenTargets
ENSG00000111700
ZINC - FDA approved
SO1B3_HUMAN
ZINC - Substances
SO1B3_HUMAN
ZINC - Biogenic
SO1B3_HUMAN
ZINC target
Q9NPD5
PRO
Q9NPD5
PDB
8PG0
ZINC - Investigational
SO1B3_HUMAN
ZINC - Metabolites
SO1B3_HUMAN
HPA
ENSG00000111700-SLCO1B3
Pharos - Targets
Q9NPD5
Orphanet
SLCO1B3
ZINC - Predictions - Purchasable
SO1B3_HUMAN
HMDB Protein
HMDBP00446
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