Reactome | LRRK2 [cytosol]

LRRK2 [cytosol]

Stable Identifier

R-HSA-5661173

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucine-rich repeat serine/threonine-protein kinase 2 ecNumber2.7.11.1/ecNumber, LRRK2_HUMAN, PARK8

Locations in the PathwayBrowser for interactor UniProt:P13473 LAMP2

Expand all

External Reference Information

External Reference

UniProt:Q5S007 LRRK2

Gene Names

LRRK2, PARK8

Chain

chain:1-2527

Reference Genes

BioGPS Gene:120892 LRRK2

COSMIC (genes):LRRK2 LRRK2

CTD Gene:120892 LRRK2

dbSNP Gene:120892 LRRK2

ENSEMBL:ENSG00000188906 LRRK2

ENSEMBL_homo_sapiens_GENE:ENSG00000188906.17 LRRK2

HGNC:18618 LRRK2

KEGG Gene (Homo sapiens):120892 LRRK2

Monarch:120892 LRRK2

NCBI Gene:120892 LRRK2

OMIM:609007 LRRK2

UCSC:Q5S007 LRRK2

Reference Transcript

RefSeq:NM_198578.3 LRRK2

Other Identifiers

11735294_a_at

11735295_a_at

120892

16749939

229584_PM_at

229584_at

3411329

3411330

3411332

3411333

3411335

3411336

3411337

3411341

3411343

3411344

3411345

3411346

3411347

3411348

3411349

3411350

3411351

3411354

3411355

3411356

3411357

3411358

3411359

3411360

3411361

3411362

3411363

3411364

3411365

3411366

3411368

3411369

3411371

3411372

3411373

3411374

3411376

3411377

3411379

3411380

3411381

3411383

3411385

3411386

3411389

3411391

3411392

3411394

3411396

3411397

3411398

3411399

3411402

3411404

3411405

3411407

3411408

3411411

3411413

3411414

3411415

51362_at

7954810

81790_at

A_23_P128447

A_33_P3369058

GE79036

GE798909

GO:0000139

GO:0000149

GO:0000165

GO:0000166

GO:0000287

GO:0001933

GO:0001934

GO:0002376

GO:0003779

GO:0003824

GO:0003924

GO:0004672

GO:0004674

GO:0004706

GO:0004709

GO:0005096

GO:0005102

GO:0005515

GO:0005524

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005759

GO:0005764

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005798

GO:0005802

GO:0005829

GO:0005856

GO:0005886

GO:0005902

GO:0006468

GO:0006606

GO:0006886

GO:0006897

GO:0006913

GO:0006914

GO:0006954

GO:0006979

GO:0007005

GO:0007029

GO:0007030

GO:0007040

GO:0007254

GO:0007266

GO:0007283

GO:0007528

GO:0008017

GO:0008021

GO:0008092

GO:0008104

GO:0008340

GO:0009267

GO:0009966

GO:0010468

GO:0010506

GO:0010508

GO:0010738

GO:0010955

GO:0010977

GO:0012501

GO:0014041

GO:0015631

GO:0016020

GO:0016192

GO:0016242

GO:0016301

GO:0016310

GO:0016323

GO:0016740

GO:0016787

GO:0017075

GO:0018105

GO:0018107

GO:0019722

GO:0021756

GO:0021772

GO:0022028

GO:0022414

GO:0023052

GO:0030154

GO:0030159

GO:0030163

GO:0030276

GO:0030424

GO:0030425

GO:0030426

GO:0030672

GO:0031267

GO:0031398

GO:0031410

GO:0031647

GO:0031966

GO:0032091

GO:0032092

GO:0032436

GO:0032473

GO:0032760

GO:0032839

GO:0034211

GO:0034260

GO:0034330

GO:0034599

GO:0034614

GO:0035556

GO:0035564

GO:0035640

GO:0035641

GO:0035751

GO:0036211

GO:0036479

GO:0039706

GO:0040012

GO:0042391

GO:0042802

GO:0042803

GO:0042995

GO:0043005

GO:0043025

GO:0043068

GO:0043195

GO:0043204

GO:0043226

GO:0043231

GO:0043406

GO:0044325

GO:0044753

GO:0044754

GO:0045121

GO:0045202

GO:0045860

GO:0046039

GO:0046777

GO:0048312

GO:0048812

GO:0048856

GO:0048870

GO:0050877

GO:0051018

GO:0051604

GO:0051646

GO:0051770

GO:0051900

GO:0051966

GO:0055086

GO:0060070

GO:0060079

GO:0060090

GO:0060159

GO:0060161

GO:0060628

GO:0060828

GO:0061001

GO:0065003

GO:0070062

GO:0070585

GO:0070971

GO:0070973

GO:0071287

GO:0071356

GO:0071407

GO:0090140

GO:0090263

GO:0090394

GO:0097487

GO:0098772

GO:0098794

GO:0098978

GO:0099400

GO:0099523

GO:0106310

GO:0140058

GO:0140096

GO:1900242

GO:1900244

GO:1901135

GO:1902236

GO:1902499

GO:1902692

GO:1902803

GO:1902823

GO:1902902

GO:1903125

GO:1903215

GO:1903217

GO:1903351

GO:1903980

GO:1904713

GO:1904887

GO:1905279

GO:1905289

GO:1990904

GO:1990909

GO:2000172

GO:2000300

GO:2000377

HMNXSV003035165

Hs.124292.0.A1_3p_at

ILMN_2226015

PH_hs_0022858

PH_hs_0041186

TC12000309.hg

Participates

as an input of

Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)

as a component of

Inferred To

LRRK2 [cytosol] (Bos taurus)

LRRK2 [cytosol] (Gallus gallus)

LRRK2 [cytosol] (Mus musculus)

LRRK2 [cytosol] (Rattus norvegicus)

LRRK2 [cytosol] (Sus scrofa)

Ghost homologue of LRRK2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_940980.3

ZINC - World Drugs

LRRK2_HUMAN

Guide to Pharmacology - Targets

2059

OpenTargets

ENSG00000188906

ZINC - FDA approved

LRRK2_HUMAN

ZINC - Substances

LRRK2_HUMAN

ZINC target

Q5S007

ZINC - Biogenic

LRRK2_HUMAN

PRO

Q5S007

PDB

6XR4, 8U7L, 2ZEJ, 6XAF, 5MY9, 8FO2, 6VP7, 8TZB, 7LHW, 7LI3, 8FO8, 8TZH, 8TYQ, 8FO7, 3D6T, 7LHT, 6VNO, 5MYC, 8TZE, 8U8B, 6DLO, 8TZF, 7LI4, 8TZG, 8FO9, 6VP6, 7THZ, 6OJF, 8TZC, 6OJE, 7THY, 8TXZ, 6DLP, 8U8A

ZINC - Investigational

LRRK2_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000188906-LRRK2

GeneCards

Q5S007

Ensembl

ENSP00000298910, ENST00000298910, ENSG00000188906

Pharos - Targets

Q5S007

Orphanet

16415

ZINC - Predictions - Purchasable

LRRK2_HUMAN

HMDB Protein

HMDBP09455

Interactors (243)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.986	68
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.976	26
UniProt:P26038 MSN	4	MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005)	0.956	19
UniProt:O00429 DNM1L	2	DNM1L [mitochondrial outer membrane] (R-HSA-351942) DNM1L [cytosol] (R-HSA-351943)	0.91	16
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.907	11
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.882	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.862	10
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.823	8
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.821	26
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.813	6
UniProt:P30048 PRDX3	1	PRDX3 [mitochondrial matrix] (R-HSA-3323081)	0.796	14
UniProt:O14976 GAK	3	GAK [cytoplasmic vesicle membrane] (R-HSA-434203) GAK [Golgi membrane] (R-HSA-434340) GAK [cytosol] (R-HSA-8868619)	0.793	11
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.788	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.788	7
GDP [ChEBI:17552]	7	GDP [lysosomal membrane] (R-ALL-9628545) GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [cilium] (R-ALL-5617810) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [nucleoplasm] (R-ALL-111349) GDP [plasma membrane] (R-ALL-114549) GDP [endoplasmic reticulum lumen] (R-ALL-1467290)	0.786	8
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.784	6
UniProt:P62841 RPS15	2	RPS15 [nucleoplasm] (R-HSA-6798706) RPS15 [cytosol] (R-HSA-72335)	0.783	9
UniProt:P61006 RAB8A	6	GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) GGC-RAB8A [cytosol] (R-HSA-8874063) RAB8A [Golgi membrane] (R-HSA-2562535) RAB8A [cytosol] (R-HSA-5623399)	0.77	9
UniProt:P61020 RAB5B	8	RAB5B [secretory granule membrane] (R-HSA-6804966) RAB5B [plasma membrane] (R-HSA-6804984) GGC-RAB5B [macropinosome membrane] (R-HSA-9837696) RAB5B [cytosol] (R-HSA-8870412) GGC-RAB5B [cytosol] (R-HSA-8870434) GGC-RAB5B [early endosome membrane] (R-HSA-8875327) RAB5B [early endosome membrane] (R-HSA-2029080) GGC-RAB5B [clathrin-coated endocytic vesicle membrane] (R-HSA-8871126)	0.761	9
UniProt:O14966 RAB29	2	GGC-RAB29 [cytosol] (R-HSA-8873957) RAB29 [cytosol] (R-HSA-8873713)	0.761	15
UniProt:Q13637 RAB32	3	GGC-RAB32 [melanosome membrane] (R-HSA-8877737) GGC-RAB32 [cytosol] (R-HSA-8873980) RAB32 [cytosol] (R-HSA-8873696)	0.753	12
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.75	5
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.744	6
IntAct:EBI-6312987 NICTIDE			0.73	4
UniProt:P05060 CHGB	2	p-CHGB [endoplasmic reticulum lumen] (R-HSA-8956928) CHGB [endoplasmic reticulum lumen] (R-HSA-8956734)	0.73	3
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.718	12
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.715	7
UniProt:P30084 ECHS1	17	Q159R ECHS1 [mitochondrial matrix] (R-HSA-9916666) F33S ECHS1 [mitochondrial matrix] (R-HSA-9916682) E77Q ECHS1 [mitochondrial matrix] (R-HSA-9916667) A138V ECHS1 [mitochondrial matrix] (R-HSA-9916683) N59S ECHS1 [mitochondrial matrix] (R-HSA-9916684) C225R ECHS1 [mitochondrial matrix] (R-HSA-9916672) ECHS1 [mitochondrial matrix] (R-HSA-54125) A2V ECHS1 [mitochondrial matrix] (R-HSA-9916688) T180A ECHS1 [mitochondrial matrix] (R-HSA-9916687) A238V ECHS1 [mitochondrial matrix] (R-HSA-9916686) A132T ECHS1 [mitochondrial matrix] (R-HSA-9916665) G195S ECHS1 [mitochondrial matrix] (R-HSA-9916681) K273E ECHS1 [mitochondrial matrix] (R-HSA-9916680) R54H ECHS1 [mitochondrial matrix] (R-HSA-9916676) I66T ECHS1 [mitochondrial matrix] (R-HSA-9916659) D150G ECHS1 [mitochondrial matrix] (R-HSA-9916674) A158D ECHS1 [mitochondrial matrix] (R-HSA-9916689)	0.713	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.713	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.713	5
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.688	4
UniProt:P61026 RAB10	5	GGC-RAB10 [cytoplasmic vesicle membrane] (R-HSA-8876076) GGC-RAB10 [cytosol] (R-HSA-8873783) RAB10 [cytosol] (R-HSA-8873669) RAB10 [plasma membrane] (R-HSA-6804816) RAB10 [secretory granule membrane] (R-HSA-6804788)	0.688	7
UniProt:Q8WUM0 NUP133	2	NUP133 [nuclear envelope] (R-HSA-157743) NUP133 [cytosol] (R-HSA-376251)	0.688	4
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.683	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.676	9
UniProt:P04350 TUBB4A	6	TUBB4A [cytosol] (R-HSA-190588) TUBB4A [axonemal microtubule] (R-HSA-5610435) Polyglutamyl-TUBB4A [cytosol] (R-HSA-8867425) Polyglycyl-TUBB4A [cytosol] (R-HSA-8867397) TUBB4A unfolded [cytosol] (R-HSA-392778) TUBB4A folding intermediate [cytosol] (R-HSA-392789)	0.67	6
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.67	18
UniProt:P39053	3	DNM1 [cytosol] (R-MMU-2213182) DNM1 [lysosomal membrane] (R-MMU-196150) DNM1 [plasma membrane] (R-MMU-177488)	0.669	3
UniProt:O95295 SNAPIN	2	SNAPIN [Golgi membrane] (R-HSA-434344) SNAPIN [cytoplasmic vesicle membrane] (R-HSA-434204)	0.66	5
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.657	4
UniProt:P61983	1	Ywhag [cytosol] (R-RNO-380312)	0.65	6
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.649	8
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.645	7
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.643	4
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.642	5
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.642	4
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.642	4
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.642	4
UniProt:P42677 RPS27	2	RPS27 [nucleoplasm] (R-HSA-6791190) RPS27 [cytosol] (R-HSA-72361)	0.642	4
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.642	4
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.642	4
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.641	4
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.64	6
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.632	5
UniProt:Q9NQU5 PAK6	1	PAK6 [cytosol] (R-HSA-428454)	0.623	2
UniProt:Q8N8V4 ANS4B			0.623	2
UniProt:P02687 MBP			0.623	3
UniProt:Q9UKI2 CDC42EP3	2	p-CDC42EP3 [cytosol] (R-HSA-5692659) CDC42EP3 [cytosol] (R-HSA-5692689)	0.623	2
ChEBI:132484 MLI-2			0.623	2
UniProt:Q96PY6 NEK1	1	NEK1 [cytosol] (R-HSA-9861542)	0.623	2
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.623	3
UniProt:Q9NWM3 CUED1			0.623	2
ChEBI:78408 GUANOSINE 5'-[BETA,GAMMA-IMIDO]TRIPHOSPHATE			0.623	5
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.623	2
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.623	4
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.623	4
UniProt:Q7L592 NDUFAF7	1	NDUFAF7 [mitochondrial matrix] (R-HSA-6788525)	0.623	2
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.621	3
UniProt:P46821-PRO_0000018605 MAP1B			0.611	5
UniProt:Q62848	1	Arfgap1 [cytosol] (R-RNO-200464)	0.61	7
UniProt:O55143	2	ATP2A2 [platelet dense tubular network membrane] (R-MMU-427903) ATP2A2 [endoplasmic reticulum membrane] (R-MMU-391962)	0.602	13
UniProt:O60313 OPA1	4	OPA1 [mitochondrial inner membrane] (R-HSA-5333636) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1 [mitochondrial inner membrane] (R-HSA-8867508)	0.602	5
UniProt:P55060 XPO2			0.597	4
UniProt:Q92973 TNPO1	2	TNPO1 [cilium] (R-HSA-5624896) TNPO1 [cytosol] (R-HSA-180743)	0.597	4
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.597	4
UniProt:P62269 RPS18	2	RPS18 [nucleoplasm] (R-HSA-6798701) RPS18 [cytosol] (R-HSA-72341)	0.59	3
UniProt:Q9Y6A4 CFA20			0.59	3
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.59	3
UniProt:Q6P3X3 TTC27			0.59	3
UniProt:O95218 ZRAB2			0.59	2
UniProt:P49406 MRPL19	1	MRPL19 [mitochondrial inner membrane] (R-HSA-5368215)	0.59	3
UniProt:Q4G0J3 LARP7			0.59	3
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.59	3
UniProt:P49207 RPL34	1	RPL34 [cytosol] (R-HSA-72458)	0.59	3
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.59	3
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.59	3
UniProt:Q9BQ70 TCF25			0.59	3
UniProt:Q9H0U4 RAB1B	8	p-T191-RAB1B [Golgi membrane] (R-HSA-2422374) RAB1B [Golgi membrane] (R-HSA-2422381) RAB1B [cytosol] (R-HSA-5685727) RAB1B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807768) RAB1B [transport vesicle] (R-HSA-6808799) GGC-RAB1B [cytosol] (R-HSA-8870426) GGC-RAB1B [transport vesicle membrane] (R-HSA-8877470) RAB1B [endoplasmic reticulum membrane] (R-HSA-6810977)	0.59	5
UniProt:Q71RC2 LARP4			0.59	3
UniProt:Q12972 PPP1R8	1	PPP1R8 [nucleoplasm] (R-HSA-9770253)	0.59	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.59	6
UniProt:Q53GS9 USP39	1	USP39 [nucleoplasm] (R-HSA-6806793)	0.59	3
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.589	5
UniProt:Q38SD2 LRRK1			0.589	5
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.571	6
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.564	3
UniProt:P05141 SLC25A5	1	SLC25A5 [mitochondrial inner membrane] (R-HSA-49743)	0.564	2
UniProt:O00203 AP3B1	4	AP3B1 [Golgi membrane] (R-HSA-434335) AP3B1 [cytoplasmic vesicle membrane] (R-HSA-434197) AP3B1(1-859)-BRAF(381-766) fusion [cytosol] (R-HSA-6802269) AP3B1(1-859)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802516)	0.564	2
UniProt:Q03252 LMNB2			0.564	3
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.564	2
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.564	3
UniProt:P12235 SLC25A4	3	SLC25A4 [mitochondrial intermembrane space] (R-HSA-1267984) SLC25A4 [cytosol] (R-HSA-1267975) AAC1 [mitochondrial inner membrane] (R-HSA-49741)	0.564	2
UniProt:P21796 VDAC1	7	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991)	0.564	3
ChEBI:78374 GPPNHP			0.558	2
UniProt:P57729 RAB38	3	GGC-RAB38 [melanosome membrane] (R-HSA-8877740) GGC-RAB38 [cytosol] (R-HSA-8873999) RAB38 [cytosol] (R-HSA-8873711)	0.558	4
UniProt:Q13469 NFATC2	4	NFATC2 [nucleoplasm] (R-HSA-3791114) p-S243-NFATC2 [cytosol] (R-HSA-2685626) p-S243-NFATC2 [nucleoplasm] (R-HSA-2025894) p-14S-NFATC2 [cytosol] (R-HSA-2025848)	0.558	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.558	6
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:Q9BUL9 RPP25	1	RPP25 [nucleoplasm] (R-HSA-5696782)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	6
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.556	5
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.554	2
UniProt:P68371 TUBB4B	8	TUBB4B [cytosol] (R-HSA-191702) TUBB4B [azurophil granule lumen] (R-HSA-6799347) TUBB4B [extracellular region] (R-HSA-6806178) TUBB4B [axonemal microtubule] (R-HSA-5610441) Polyglutamyl-TUBB4B [cytosol] (R-HSA-8867427) Polyglycyl-TUBB4B [cytosol] (R-HSA-8867452) TUBB4B unfolded [cytosol] (R-HSA-392779) TUBB4B folding intermediate [cytosol] (R-HSA-392788)	0.547	3
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.547	3
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.547	3
UniProt:Q8N6T3-2 ARFGAP1			0.544	6
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.543	4
UniProt:O14640-2 DVL1			0.543	7
UniProt:Q9Y6I7 WSB1	1	WSB1 [cytosol] (R-HSA-976016)	0.543	5
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.543	4
UniProt:Q9DBG3	5	Ap2b1 [endolysosome membrane] (R-MMU-6784827) Ap2b1 [endocytic vesicle membrane] (R-MMU-416642) Ap2b1 [plasma membrane] (R-MMU-167690) Ap2b1 [clathrin-coated endocytic vesicle membrane] (R-MMU-2130489) Ap2b1 [cytosol] (R-MMU-182166)	0.527	2
UniProt:Q9JIS5 SV2A			0.527	2
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.527	3
UniProt:Q68FD5	6	Cltc [cytosol] (R-MMU-350824) Cltc [trans-Golgi network membrane] (R-MMU-2130474) Cltc [endolysosome membrane] (R-MMU-8870827) Cltc [clathrin-coated endocytic vesicle membrane] (R-MMU-5138450) Cltc [lysosomal membrane] (R-MMU-2980660) Cltc [plasma membrane] (R-MMU-2980668)	0.527	2
UniProt:P62259 Ywhae	1	14-3-3 epsilon [cytosol] (R-MMU-1445119)	0.527	2
UniProt:P14618 PKM	3	PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.527	3
UniProt:P39023 RPL3	1	RPL3 [cytosol] (R-HSA-72448)	0.527	3
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.527	3
UniProt:Q01813 PFKP	1	PFKP [cytosol] (R-HSA-71452)	0.527	3
UniProt:O00159 MYO1C	1	MYO1C [cytosol] (R-HSA-1449619)	0.527	3
UniProt:P10155 RO60			0.527	3
UniProt:P61264	1	Stx1b [plasma membrane] (R-MMU-181479)	0.527	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	3
UniProt:Q96T76 MMS19	1	MMS19 [cytosol] (R-HSA-2161121)	0.527	3
UniProt:Q9NU22 MDN1			0.527	3
UniProt:P23258 TUBG1	1	TUBG1 [cytosol] (R-HSA-379269)	0.527	3
UniProt:Q9P035 HACD3	1	PTPLAD1 [endoplasmic reticulum membrane] (R-HSA-5676074)	0.527	3
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:P83731 RPL24	1	RPL24 [cytosol] (R-HSA-72434)	0.527	3
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.527	3
UniProt:P49411 TUFM	2	TUFM [mitochondrial matrix] (R-HSA-5389846) TUFM [mitochondrial outer membrane] (R-HSA-9754777)	0.527	3
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.527	3
UniProt:O43795 MYO1B			0.527	3
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.527	3
UniProt:P12270 TPR	5	TPR M489P [nucleoplasm] (R-HSA-5661477) TPR L458P [nucleoplasm] (R-HSA-5661460) TPR(2-629)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711958) TPR(2-629)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711979) TPR [nucleoplasm] (R-HSA-157692)	0.527	3
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	3
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.527	3
UniProt:P09543 CN37			0.527	3
UniProt:P68373 Tuba1c	6	AcK-TUBA1C [cytosol] (R-MMU-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-MMU-5624856) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-MMU-8867405) Polyglutamyl-TUBA1C [cytosol] (R-MMU-8867401) TUBA1C [axonemal microtubule] (R-MMU-5610439) Tubulin alpha-1C chain [cytosol] (R-MMU-2316300)	0.527	2
UniProt:Q8N1G4 LRC47			0.527	3
UniProt:Q8NI60 COQ8A	1	COQ8A [mitochondrial inner membrane] (R-HSA-9856284)	0.527	3
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.527	3
UniProt:O15269 SPTLC1	1	PXLP-K-SPTLC1 [endoplasmic reticulum membrane] (R-HSA-428155)	0.527	3
UniProt:P99024 Tubb5	4	beta 5 tubulin [cytosol] (R-MMU-391459) unfolded beta 5 tubulin [cytosol] (R-MMU-391398) TUBB [azurophil granule lumen] (R-MMU-6799370) TUBB [extracellular region] (R-MMU-380317)	0.527	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.527	2
UniProt:P57740 NUP107	2	NUP107 [nuclear envelope] (R-HSA-157717) NUP107 [cytosol] (R-HSA-376241)	0.527	3
UniProt:Q9H9B4 SFXN1			0.527	3
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.527	3
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.527	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	3
UniProt:Q969V3 NCLN			0.527	3
UniProt:O95831 AIFM1			0.527	3
UniProt:O00139 KIF2A	1	KIF2A [cytosol] (R-HSA-376232)	0.527	3
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.527	3
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	3
UniProt:Q61548	1	Snap91 [cytosol] (R-MMU-8867597)	0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	3
UniProt:Q12769 NUP160	2	NUP160 [nuclear envelope] (R-HSA-157721) NUP160 [cytosol] (R-HSA-376253)	0.527	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.527	3
UniProt:Q5S006	1	LRRK2 [cytosol] (R-MMU-5661173)	0.527	2
UniProt:Q7L576 CYFIP1	5	CYFIP1 [specific granule lumen] (R-HSA-6800167) CYFIP1 [secretory granule lumen] (R-HSA-6800940) CYFIP1 [extracellular region] (R-HSA-6800473) CYFIP1 [tertiary granule lumen] (R-HSA-6800176) CYFIP1 [cytosol] (R-HSA-5672575)	0.527	3
UniProt:P48047 ATP5PO	1	ATP5PO [mitochondrial inner membrane] (R-HSA-164533)	0.527	3
UniProt:P51571 SSR4	1	SSR4 [endoplasmic reticulum membrane] (R-HSA-265026)	0.527	3
UniProt:P30050 RPL12	1	RPL12 [cytosol] (R-HSA-72408)	0.527	3
UniProt:P13995 MTHFD2	1	MTHFD2 [mitochondrial matrix] (R-HSA-6801347)	0.527	3
UniProt:Q9H936 SLC25A22	1	SLC25A22 [mitochondrial inner membrane] (R-HSA-5216091)	0.527	3
UniProt:P11216 PYGB	4	PXLP-PYGB [extracellular region] (R-HSA-6801536) PXLP-PYGB [azurophil granule lumen] (R-HSA-6799164) PXLP-p-S15-PYGB [cytosol] (R-HSA-71868) PXLP-PYGB [cytosol] (R-HSA-71862)	0.527	3
UniProt:Q9UNF1 MAGED2	2	MAGED2 [extracellular region] (R-HSA-8862948) MAGED2 [platelet alpha granule lumen] (R-HSA-8862956)	0.527	3
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.527	3
UniProt:O60610 DIAPH1	4	DIAPH1 [ficolin-1-rich granule membrane] (R-HSA-6801388) DIAPH1 [plasma membrane] (R-HSA-6801557) DIAPH1 [secretory granule membrane] (R-HSA-6801368) DIAPH1 [cytosol] (R-HSA-5665970)	0.527	2
UniProt:Q14008 CKAP5	1	CKAP5 [cytosol] (R-HSA-377729)	0.527	3
UniProt:P42166 TMPO			0.527	3
UniProt:Q13724 MOGS	3	MOGS F652L [endoplasmic reticulum membrane] (R-HSA-4839779) MOGS R486T [endoplasmic reticulum membrane] (R-HSA-4839818) MOGS [endoplasmic reticulum membrane] (R-HSA-532676)	0.527	3
UniProt:P05213 Tuba1b	10	AcK-TUBA1B [cytosol] (R-MMU-5618285) Ac K40 TUBA1B [axonemal microtubule] (R-MMU-5624854) unfolded alpha 2 tubulin [cytosol] (R-MMU-391420) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-MMU-8867436) L-isoglutamyl polyglycyl-TUBA4B [cytosol] (R-MMU-8867412) Polyglutamyl-TUBA4B [cytosol] (R-MMU-8867417) Polyglutamyl-TUBA1B [cytosol] (R-MMU-8867435) TUBA1B [axonemal microtubule] (R-MMU-5610434) Tubulin alpha-1B chain [cytosol] (R-MMU-2316298) TUBA4B [cytosol] (R-MMU-6805236)	0.527	2
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.527	3
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.527	3
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.527	3
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	3
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.527	3
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.527	3
UniProt:P62263 RPS14	2	RPS14 [nucleoplasm] (R-HSA-6790669) RPS14 [cytosol] (R-HSA-72333)	0.527	3
UniProt:P62081 RPS7	2	RPS7 [nucleoplasm] (R-HSA-6790635) RPS7 [cytosol] (R-HSA-72383)	0.527	3
UniProt:O00273 DFFA	6	DFFA [cytosol] (R-HSA-211221) DFFA(1-?) [nucleoplasm] (R-HSA-211228) DFFA(225-331) [nucleoplasm] (R-HSA-211188) DFFA(118-224) [nucleoplasm] (R-HSA-211205) DFFA(118-331) [nucleoplasm] (R-HSA-211199) DFFA(1-117) [nucleoplasm] (R-HSA-211185)	0.527	3
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.527	3
UniProt:Q92945 KHSRP	4	p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.527	3
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.527	3
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	3
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.527	3
UniProt:O35526 Stx1a	3	Stx1a [cytosol] (R-MMU-9609866) Syntaxin-1A [plasma membrane] (R-MMU-216884) Stx1a [plasma membrane] (R-MMU-449128)	0.527	2
UniProt:P07901 Hsp90aa1	7	HSP90AA1 [secretory granule lumen] (R-MMU-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-MMU-6801470) HSP90AA1 [plasma membrane] (R-MMU-534996) HSP90AA1 [extracellular region] (R-MMU-3221946) HSP90AA1 [nucleoplasm] (R-MMU-5082401) Hsp90aa1 [cytosol] (R-MMU-5605275) HSP90AA1 [cytosol] (R-MMU-192864)	0.527	2
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.527	3
UniProt:P49792 RANBP2	6	polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [cytosol] (R-HSA-157703)	0.527	3
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.527	3
UniProt:P62244 RPS15A	2	RPS15A [nucleoplasm] (R-HSA-6791191) RPS15A [cytosol] (R-HSA-72345)	0.527	3
UniProt:P61221 ABCE1	2	ABCE1 [cytosol] (R-HSA-8985209) ABCE1 [mitochondrial matrix] (R-HSA-5216010)	0.527	3
UniProt:Q86WJ1 CHD1L	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.527	3
UniProt:P00338 LDHA	2	PolyUb-LDHA [cytosol] (R-HSA-9861549) LDHA [cytosol] (R-HSA-70502)	0.527	3
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	3
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.527	3
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.527	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.527	3
UniProt:P43246 MSH2	3	MSH2 R406* [nucleoplasm] (R-HSA-5575594) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243)	0.527	3
UniProt:P11499	5	HSP90AB1 [secretory granule lumen] (R-MMU-6801477) HSP90AB1 [extracellular region] (R-MMU-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-MMU-6801491) HSP90AB1 [cytosol] (R-MMU-419617) HSP90AB1 [nucleoplasm] (R-MMU-5082399)	0.527	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	3
UniProt:P46782 RPS5	2	RPS5 [nucleoplasm] (R-HSA-6791188) RPS5 [cytosol] (R-HSA-72379)	0.527	3
UniProt:P13639 EEF2	10	EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	3
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.527	3
UniProt:P46460	1	NSF [cytosol] (R-MMU-264471)	0.527	5
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.527	3
UniProt:P62266 RPS23	3	3OHP62-RPS23 [nucleoplasm] (R-HSA-9630773) RPS23 [nucleoplasm] (R-HSA-6791209) RPS23 [cytosol] (R-HSA-72353)	0.525	2
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.525	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.525	2
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.525	2
UniProt:P12369 Prkar2b	3	cAMP-dependent protein kinase type II-beta regulatory subunit [cytosol] (R-RNO-446975) PRKAR2B [ciliary base] (R-RNO-5610414) PRKAR2B [cytosol] (R-RNO-57842)	0.524	3
UniProt:P30275	1	CKMT1A [mitochondrial inner membrane] (R-MMU-200361)	0.524	2
UniProt:P61021	6	GGC-RAB5B [clathrin-coated endocytic vesicle membrane] (R-MMU-8871126) GGC-RAB5B [early endosome membrane] (R-MMU-8875327) GGC-RAB5B [cytosol] (R-MMU-8870434) RAB5B [cytosol] (R-MMU-8870412) RAB5B [plasma membrane] (R-MMU-6804984) RAB5B [secretory granule membrane] (R-MMU-6804966)	0.499	2
UniProt:Q6IQ22 RAB12	3	GGC-RAB12 [recycling endosome membrane] (R-HSA-8876449) GGC-RAB12 [cytosol] (R-HSA-8873777) RAB12 [cytosol] (R-HSA-8873672)	0.499	2
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.499	4
UniProt:Q13509 TUBB3	6	TUBB3 folding intermediate [cytosol] (R-HSA-392806) TUBB3 unfolded [cytosol] (R-HSA-392770) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) TUBB3 [axonemal microtubule] (R-HSA-5610436) TUBB3 [cytosol] (R-HSA-190532)	0.482	2
UniProt:Q91YQ1	2	GGC-RAB29 [cytosol] (R-MMU-8873957) RAB29 [cytosol] (R-MMU-8873713)	0.463	2
UniProt:Q63481	2	GGC-RAB29 [cytosol] (R-RNO-8873957) RAB29 [cytosol] (R-RNO-8873713)	0.463	3
UniProt:O95140 MFN2	5	MFN2 [mitochondrial outer membrane] (R-HSA-992714) Ub-MFN2 [mitochondrial outer membrane] (R-HSA-9835010) K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) K63polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-9834043) p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-HSA-9834980)	0.463	3
UniProt:Q811U4	5	MFN1 [mitochondrial outer membrane] (R-MMU-992745) Ub-MFN1 [mitochondrial outer membrane] (R-MMU-9834985) K48polyUb-MFN1 [mitochondrial outer membrane] (R-MMU-5205679) K63polyUb-MFN1 [mitochondrial outer membrane] (R-MMU-9834040) p-S65-Ub:MFN1 [mitochondrial outer membrane] (R-MMU-9835008)	0.463	3
UniProt:Q32KD4	6	AGO1 [nucleoplasm] (R-DME-5578686) AGO1 [nucleoplasm] (R-DME-5578701) AGO1 [cytosol] (R-DME-209723) AGO1 [cytosol] (R-DME-210616) AGO1 [cytosol] (R-DME-210612) AGO1 [cytosol] (R-DME-210615)	0.463	2
UniProt:P13473 LAMP2	5	LAMP2 [platelet dense granule membrane] (R-HSA-58648) LAMP2 [ficolin-1-rich granule membrane] (R-HSA-6800941) LAMP2 [plasma membrane] (R-HSA-114679) LAMP2 [azurophil granule membrane] (R-HSA-6799150) LAMP2 [lysosomal membrane] (R-HSA-2029007)	0.463	2
UniProt:P52564 MAP2K6	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.463	4
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.462	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.462	2

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