Reactome | CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3

CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3

Stable Identifier

R-HSA-5661117

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CCND1:CDK4:PRMT5:pT5-WDR77 methylates MeR9-histone H3

ReviewStatus

5/5

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CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3

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Histone H3 arginine-9 (H3R8) dimethylation is a PRMT5-specific mark (Pal et al. 2004) associated with gene silencing (Chen et al. 1999, Pal et al. 2004, 2007).

Literature References

PubMed ID	Title	Journal	Year
15485929	Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes Vishwanath, SN, Pal, S, Sif, S, Tempst, P, Erdjument-Bromage, H	Mol. Cell. Biol.	2004