Reactome | KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3

KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3

Stable Identifier

R-HSA-5661115

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3

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All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine epsilon-amine group and consequently JmjC containing demethylases are able to catalyse demethylateion of tri , di and monomethylated lysines. KDM3A (JHDM2A), KDM3B (JHDM2B), KDM7A (JHDM1D), PHF8 (JHDM1E) and PHF2 when complexed with ARID5B (Wen et al. 2010, Baba et al. 2011) are specific for mono or di-methylated lysine-10 on histone H3 (H3K9Me1/2) (Yamane et al. 2006, Kim et al. 2012, Horton et al. 2010, Huang et al. 2010, Loenarz et al. 2008, Feng et al. 2010, Fortschegger et al. 2010, Qi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20129925	Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation Sha, B, Lee, MG, Li, J, Song, T, Wen, H, Lu, M, Shi, X, Kan, PY	J. Biol. Chem.	2010
20084082	Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4 Xiang, Y, Zhu, Q, Li, X, Jing, N, Xu, L, Huang, C, Chen, CD, Zhang, K, Zhu, Z, Wang, Y, Zhang, T	Cell Res.	2010
19843542	PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase Cooper, CD, Klose, RJ, Coleman, ML, Ratcliffe, PJ, Schofield, CJ, Ge, W, Rose, NR, Loenarz, C	Hum. Mol. Genet.	2010
21532585	PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B Brown, M, Okada, M, Ohtake, F, Baba, A, Igarashi, K, Yokota, K, Ni, M, Imai, Y, Okuno, Y, Kanno, J, Meyer, CA, Kato, S	Nat. Cell Biol.	2011
22615488	KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia Kee, HJ, Baek, HJ, Choe, N, Kim, DW, Pak, JH, Kim, JY, Kook, H, Oh, ST, Kook, H, Son, HJ, Seo, SB, Kim, KB, Chakravarti, D, Eom, GH, Hahn, Y	Mol. Cell. Biol.	2012
16603237	JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor Toumazou, C, Tsukada, Y, Yamane, K, Zhang, Y, Tempst, P, Wong, J, Erdjument-Bromage, H	Cell	2006
20208542	PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation Jenuwein, T, Feng, W, Ye, J, Yonezawa, M, Grummt, I	Nat. Struct. Mol. Biol.	2010
20023638	Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases Shi, Y, Zhang, X, Upadhyay, AK, Horton, JR, Cheng, X, Qi, HH	Nat. Struct. Mol. Biol.	2010