Reactome | p-S276-RELA binds RELB

p-S276-RELA binds RELB

Stable Identifier

R-HSA-5660980

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylated RELA besides undergoing further acetylation by the histone acetyltransferases (HATs) CBP and p300 also forms a complex with RELB to form inactive RELA-RELB dimers that cannot bind DNA. Because RELB requires p50 or p52 as a dimerization partner to bind DNA, it is possible that sequestration of RELB from its complex partners p50 and p52 by RELA might account for the lack of RELB DNA binding. RELA-RELB dimers have important regulatory consequences on dectin-1 mediated non-canonical NF-kB pathway. Inactive p65-RELB dimers blocks binding of RELB-p52 to the promoters of the chemokine genes CCL17 (CC-chemokine ligand 17) and CCL22, thereby blocking chemokine expression (Gringhuis et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19122653	Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Wevers, B, Litjens, M, Geijtenbeek, TB, Bruijns, SC, Gringhuis, SI, den Dunnen, J, van der Vlist, M	Nat. Immunol.	2009