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MTF1 dimer:12Zn2+ binds CSRP1 gene
Stable Identifier
R-HSA-5660514
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Response to metal ions (Homo sapiens)
MTF1 activates gene expression (Homo sapiens)
MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As inferred from the mouse homolog, the promoter of the CSRP1 gene contains 3 consensus metal response elements, at least one of which binds MTF1. Expression of CSRP1 is activated by cadmium via MTF1.
Participants
Input
CSRP1 gene [nucleoplasm]
(Homo sapiens)
MTF1 dimer:12Zn2+ [nucleoplasm]
(Homo sapiens)
Output
MTF1 dimer:12Zn2+:CSRP1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
MTF1 activates gene expression (Homo sapiens)
Inferred From
Mtf1 dimer:12Zn2+ binds Csrp1 gene (Mus musculus)
Authored
May, B (2014-12-28)
Reviewed
Ford, D (2017-01-27)
Created
May, B (2015-01-05)
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