Expression of CSRP1

Stable Identifier
R-HSA-5660503
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of CSRP1
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The CSRP1 gene is transcribed to yield mRNA which is translated to yield protein. Expression of CSRP1 is activated by zinc via MTF1 (Hardyman et al. 2016). As inferred from the mouse homolog, expression of CSRP1 is activated by cadmium via MTF1.

As inferred from mouse homologs, MTF1 binds and activates the CSRP1 promoter (Wimmer et al. 2005).

Literature References
PubMed ID Title Journal Year
1374386 Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc

Cooke, NE, Lee, G, Wang, X, Liebhaber, SA

J. Biol. Chem. 1992
26824222 Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc

Wakeling, LA, Hardyman, JE, Valentine, RA, Aldridge, C, Tyson, J, Jackson, KA, Ford, D, Cockell, SJ

Metallomics 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MTF1 dimer:12Zn2+:CSRP1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Csrp1 (Mus musculus)
Authored
May, B  (2014-12-28)
Reviewed
Ford, D  (2017-01-27)
Created
May, B  (2015-01-05)
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