BRCA1 and BARD1 form a stable heterodimer through an interaction between sequences encompassing their N-terminal RING domains (Wu et al. 1996, Brzovic et al. 2001). In addition to the RING domains, BRCA1 and BARD1 both have tandem BRCT motifs at their C termini. The central region of BARD1 contains ankyrin repeats (Wu et al. 1996). Formation of BRCA1:BARD1 heterodimers is necessary for the repair of double-strand DNA breaks by homologous recombination (Westermark et al. 2003, Laufer et al. 2007), BRCA1-mediated tumor suppression (Shakya et al. 2008) and normal development (McCarthy et al. 2003). Tumorigenic BRCA1 mutations that abolish the formation of BRCA1:BARD1 heterodimers have been reported (Wu et al. 1996, Brzovic et al. 2001).
Szabolcs, M, Baer, RJ, Ludwig, T, Shakya, R, Basso, K, Ospina, E, Nandula, S, Murty, V, McCarthy, E
Murty, VV, Nandula, SV, Baer, RJ, Jasin, M, Ludwig, T, Modi, AP, Laufer, M, Wang, S
King, MC, Hoyt, DW, Rajagopal, P, Brzovic, PS, Klevit, RE
Phung, A, Bowcock, AM, Wu, LC, Hwang, LY, Wang, ZW, Baer, R, Yang, MC, Spillman, MA, Xu, XL, Tsan, JT
Baer, RJ, Jasin, M, Moynahan, ME, Westermark, UK, Olshen, AB, Reyngold, M
McCarthy, EE, Baer, RJ, Ludwig, T, Celebi, JT
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