BRCA1 and BARD1 form a stable heterodimer through an interaction between sequences encompassing their N-terminal RING domains (Wu et al. 1996, Brzovic et al. 2001). In addition to the RING domains, BRCA1 and BARD1 both have tandem BRCT motifs at their C termini. The central region of BARD1 contains ankyrin repeats (Wu et al. 1996). Formation of BRCA1:BARD1 heterodimers is necessary for the repair of double strand DNA breaks by homologous recombination (Westermark et al. 2003, Laufer et al. 2007), BRCA1-mediated tumor suppression (Shakya et al. 2008) and normal development (McCarthy et al. 2003). Tumorigenic BRCA1 mutations that abolish the formation of BRCA1:BARD1 heterodimers have been reported (Wu et al. 1996, Brzovic et al. 2001).
Laufer, M, Nandula, SV, Modi, AP, Wang, S, Jasin, M, Murty, VV, Ludwig, T, Baer, RJ
Shakya, R, Szabolcs, M, McCarthy, E, Ospina, E, Basso, K, Nandula, S, Murty, V, Baer, RJ, Ludwig, T
Brzovic, PS, Rajagopal, P, Hoyt, DW, King, MC, Klevit, RE
Wu, LC, Wang, ZW, Tsan, JT, Spillman, MA, Phung, A, Xu, XL, Yang, MC, Hwang, LY, Bowcock, AM, Baer, R
Westermark, UK, Reyngold, M, Olshen, AB, Baer, RJ, Jasin, M, Moynahan, ME
McCarthy, EE, Celebi, JT, Baer, RJ, Ludwig, T
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