NF1 is degraded by the proteasome

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After ubiquitination by the CUL3:KBTBD7 E3 RING ligase complex, NF1 is degraded by the proteasome (Cichowski et al, 2003; McGillicuddy et al, 2009; Hollstein et al, 2013).

Literature References
PubMed ID Title Journal Year
12600938 Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

Jacks, T, Jardim, M, Cichowski, K, Johnson, BW, Santiago, S

Genes Dev. 2003
23661552 Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras

Cichowski, K, Hollstein, PE

Cancer Discov 2013
19573811 Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

Stemmer-Rachamimov, AO, Moldenhauer, G, Fromm, JA, Liau, LM, Kubek, S, Cichowski, K, Parret, A, Mellinghoff, IK, Messiaen, L, Mischel, PS, Sawyers, CL, De Raedt, T, Scheffzek, K, Seiler, J, Beroukhim, R, Cloughesy, TF, Williams, SM, Brennan, C, McGillicuddy, LT, Johnson, BW, Hollstein, PE, Nghiemphu, P

Cancer Cell 2009
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
Cite Us!