NF1 is degraded by the proteasome

Stable Identifier
R-HSA-5658430
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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After ubiquitination by the CUL3:KBTBD7 E3 RING ligase complex, NF1 is degraded by the proteasome (Cichowski et al, 2003; McGillicuddy et al, 2009; Hollstein et al, 2013).

Literature References
PubMed ID Title Journal Year
23661552 Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras

Hollstein, PE, Cichowski, K

Cancer Discov 2013
12600938 Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

Cichowski, K, Santiago, S, Jardim, M, Johnson, BW, Jacks, T

Genes Dev. 2003
19573811 Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

McGillicuddy, LT, Fromm, JA, Hollstein, PE, Kubek, S, Beroukhim, R, De Raedt, T, Johnson, BW, Williams, SM, Nghiemphu, P, Liau, LM, Cloughesy, TF, Mischel, PS, Parret, A, Seiler, J, Moldenhauer, G, Scheffzek, K, Stemmer-Rachamimov, AO, Sawyers, CL, Brennan, C, Messiaen, L, Mellinghoff, IK, Cichowski, K

Cancer Cell 2009
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
Authored
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