Reactome | NF1 is degraded by the proteasome

NF1 is degraded by the proteasome

Stable Identifier

R-HSA-5658430

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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After ubiquitination by the CUL3:KBTBD7 E3 RING ligase complex, NF1 is degraded by the proteasome (Cichowski et al, 2003; McGillicuddy et al, 2009; Hollstein et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
12600938	Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor Jacks, T, Jardim, M, Cichowski, K, Johnson, BW, Santiago, S	Genes Dev.	2003
23661552	Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras Cichowski, K, Hollstein, PE	Cancer Discov	2013
19573811	Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis Stemmer-Rachamimov, AO, Moldenhauer, G, Fromm, JA, Liau, LM, Kubek, S, Cichowski, K, Parret, A, Mellinghoff, IK, Messiaen, L, Mischel, PS, Sawyers, CL, De Raedt, T, Scheffzek, K, Seiler, J, Beroukhim, R, Cloughesy, TF, Williams, SM, Brennan, C, McGillicuddy, LT, Johnson, BW, Hollstein, PE, Nghiemphu, P	Cancer Cell	2009