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SPRED3 [plasma membrane]
Stable Identifier
R-HSA-5658223
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
RAS signaling downstream of NF1 loss-of-function variants (Homo sapiens)
Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)
NF1 GTPase mutants:SPRED dimer:p21 RAS:GTP [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
SPRED dimer:ub-NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
SPRED dimer:ub-NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
RAS GAPs bind RAS:GTP (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
SPRED dimer binds NF1 (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED3 dimer [plasma membrane] (Homo sapiens)
SPRED3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q2MJR0 SPRED3
Gene Names
SPRED3, EVE-3
Chain
chain:1-410
Reference Genes
BioGPS Gene:399473 SPRED3
COSMIC (genes):SPRED3 SPRED3
CTD Gene:399473 SPRED3
dbSNP Gene:399473 SPRED3
ENSEMBL:ENSG00000188766 SPRED3
HGNC:31041 SPRED3
KEGG:hsa:399473 SPRED3
Monarch:399473 SPRED3
NCBI Gene:399473 SPRED3
OMIM:609293 SPRED3
UCSC:Q2MJR0 SPRED3
Reference Transcript
RefSeq:XM_006723219.3 SPRED3
RefSeq:NM_001042522.2 SPRED3
Other Identifiers
11735564_at
11738951_a_at
16861714
230046_PM_at
230046_at
3832407
3832408
3832409
3832410
3832411
3832412
3832413
3832414
3832415
3832416
3832417
3832418
3832419
3832420
3832421
3832422
3832423
3832424
3832425
3832426
3832427
3832428
3832429
3832431
3832432
3832434
399473
77755_at
8028389
A_33_P3401980
A_33_P3401981
GE505778
GE507652
GO:0005886
GO:0007275
GO:0009966
GO:0010719
GO:0016020
GO:0019901
GO:0030512
GO:0043409
GO:0048856
GO:0070373
GO:1902747
HMNXSV003008160
Hs.196011.0.A1_3p_at
ILMN_1651609
ILMN_2275110
ILMN_2410194
PH_hs_0033689
TC19000528.hg
Participates
as a component of
SPRED3 dimer [plasma membrane] (Homo sapiens)
Inferred To
Spred [plasma membrane]
(Drosophila melanogaster)
spred3 [plasma membrane]
(Xenopus tropicalis)
Spred3 [plasma membrane]
(Mus musculus)
Spred3 [plasma membrane]
(Rattus norvegicus)
SPRED3 [plasma membrane]
(Canis familiaris)
SPRED3 [plasma membrane]
(Sus scrofa)
vasp [plasma membrane]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENSP00000345405
,
ENSP00000510478
,
ENST00000691638
,
ENSG00000188766
,
ENST00000586301
,
ENST00000338502
,
ENSP00000466568
OpenTargets
ENSG00000188766
GeneCards
SPRED3
HPA
ENSG00000188766-SPRED3
PRO
Q2MJR0
Pharos - Targets
Q2MJR0
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