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SPRED dimer [plasma membrane]
Stable Identifier
R-HSA-5658219
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
RAS signaling downstream of NF1 loss-of-function variants (Homo sapiens)
Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)
NF1 GTPase mutants:SPRED dimer:p21 RAS:GTP [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED dimer:ub-NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED dimer:ub-NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
RAS GAPs bind RAS:GTP (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED dimer binds NF1 (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
SPRED dimer [plasma membrane] (Homo sapiens)
Participants
members
SPRED1 dimer [plasma membrane]
(Homo sapiens)
candidates
SPRED2 dimer [plasma membrane]
(Homo sapiens)
SPRED3 dimer [plasma membrane]
(Homo sapiens)
Participates
as a component of
NF1 GTPase mutants:SPRED dimer:p21 RAS:GTP [plasma membrane] (Homo sapiens)
SPRED dimer:ub-NF1 [plasma membrane] (Homo sapiens)
SPRED dimer:NF1 [plasma membrane] (Homo sapiens)
as an output of
NF1 is degraded by the proteasome (Homo sapiens)
as an input of
SPRED dimer binds NF1 (Homo sapiens)
Inferred To
SPRED dimer [plasma membrane]
(Canis familiaris)
SPRED dimer [plasma membrane]
(Danio rerio)
SPRED dimer [plasma membrane]
(Dictyostelium discoideum)
SPRED dimer [plasma membrane]
(Drosophila melanogaster)
SPRED dimer [plasma membrane]
(Gallus gallus)
SPRED dimer [plasma membrane]
(Mus musculus)
SPRED dimer [plasma membrane]
(Rattus norvegicus)
SPRED dimer [plasma membrane]
(Sus scrofa)
SPRED dimer [plasma membrane]
(Xenopus tropicalis)
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