SNCAIP binds alpha-synuclein

Stable Identifier
R-HSA-5658104
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SNCAIP binds alpha-synuclein
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Synphilin-1 (SNCAIP) binds alpha-synuclein (SNCAs) in vivo, which promotes the formation of Lewy body-like inclusions that are characteristic of Parkinson's Disease (Engelender et al. 1999, Kawamata et al. 2001). SNCAIP and PARK2 (Parkin) are found in the central core of a majority of Lewy Bodies in Parkinson's disease (Bandopadhyay et al. 2005).
Literature References
PubMed ID Title Journal Year
10319874 Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Engelender, S, Kaminsky, Z, Guo, X, Sharp, AH, Amaravi, RK, Kleiderlein, JJ, Margolis, RL, Troncoso, JC, Lanahan, AA, Worley, PF, Dawson, VL, Dawson, TM, Ross, CA

Nat. Genet. 1999
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Authored
Jupe, S  (2014-12-17)
Reviewed
Perry, G  (2015-11-09)
Created
Jupe, S  (2014-12-17)
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