ALKBH2 binds alkylated DNA containing 1-meA

Stable Identifier
R-HSA-5657641
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ALKBH2 binds alkylated DNA containing 1-meA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ALKBH2 binds alkylated DNA containing 1-methyladenine (1-meA). ALKBH2 preferentially binds double strand DNA (dsDNA) (Duncan et al. 2002, Aas et al. 2003, Chen et al. 2010). Iron (Fe2+) is needed for the catalytic activity of ALKBH2 (Duncan et al. 2002).
Literature References
PubMed ID Title Journal Year
12594517 Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

Aas, PA, Otterlei, M, Falnes, PO, Vågbø, CB, Skorpen, F, Akbari, M, Sundheim, O, Bjørås, M, Slupphaug, G, Seeberg, E, Krokan, HE

Nature 2003
20714506 Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3

Chen, B, Liu, H, Sun, X, Yang, CG

Mol Biosyst 2010
12486230 Reversal of DNA alkylation damage by two human dioxygenases.

Duncan, T, Trewick, SC, Koivisto, P, Bates, PA, Lindahl, T, Sedgwick, B

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Participates
as an event of
Authored
Pegg, AE  (2004-02-04)
Reviewed
Joshi-Tope, G  (2004-02-04)
Gillespie, ME  (2015-02-06)
Created
Orlic-Milacic, M  (2014-12-16)
Cite Us!