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ASCC2 [nucleoplasm]
Stable Identifier
R-HSA-5656395
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Activating signal cointegrator 1 complex subunit 2, Trip4 complex subunit p100, ASC-1 complex subunit p100, ASC1P100
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Reversal (Homo sapiens)
Reversal of alkylation damage by DNA dioxygenases (Homo sapiens)
ALKBH3 mediated reversal of alkylation damage (Homo sapiens)
ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:3-meC-dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:3-meC-dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
ASCC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H1I8 ASCC2
Gene Names
ASCC2, ASC1P100, RQT3
Chain
chain:1-757
Reference Genes
BioGPS Gene:84164 ASCC2
COSMIC (genes):ASCC2 ASCC2
CTD Gene:84164 ASCC2
dbSNP Gene:84164 ASCC2
ENSEMBL:ENSG00000100325 ASCC2
HGNC:24103 ASCC2
KEGG:hsa:84164 ASCC2
Monarch:84164 ASCC2
NCBI Gene:84164 ASCC2
OMIM:614216 ASCC2
UCSC:Q9H1I8 ASCC2
Reference Transcript
RefSeq:XM_017029000.1 ASCC2
RefSeq:XM_017028999.1 ASCC2
RefSeq:XM_017028998.1 ASCC2
RefSeq:NM_032204.4 ASCC2
RefSeq:XM_005261775.2 ASCC2
RefSeq:NM_001242906.1 ASCC2
Other Identifiers
11717449_a_at
16933703
215684_PM_s_at
215684_s_at
36058_at
3957004
3957005
3957006
3957007
3957008
3957010
3957012
3957013
3957014
3957015
3957016
3957022
3957024
3957025
3957026
3957027
3957028
3957029
3957030
3957031
3957032
3957033
3957034
3957035
3957036
3957037
3957038
3957039
3957040
3957041
3957042
3957044
3957045
3957048
3957056
3957057
3957058
3957059
3957060
3957061
3957062
3957064
78209_at
78212_g_at
78214_f_at
78217_r_at
8075285
84164
89451_at
A_23_P143643
GE56381
GO:0005515
GO:0005634
GO:0005654
GO:0005840
GO:0006281
GO:0006307
GO:0006355
GO:0016607
GO:0022626
GO:0030163
GO:0032508
GO:0032790
GO:0043130
GO:0043226
GO:0070530
GO:0072344
GO:0099053
GO:1990116
GO:1990391
HMNXSV003014363
Hs.49005.2.A1_3p_a_at
ILMN_1679919
PH_hs_0033388
TC22000642.hg
Participates
as a component of
ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
Inferred To
ASCC2 [nucleoplasm]
(Bos taurus)
ASCC2 [nucleoplasm]
(Canis familiaris)
ASCC2 [nucleoplasm]
(Gallus gallus)
ASCC2 [nucleoplasm]
(Sus scrofa)
ascc2 [nucleoplasm]
(Danio rerio)
ascc2 [nucleoplasm]
(Xenopus tropicalis)
Dmel\CG2701 [nucleoplasm]
(Drosophila melanogaster)
Ascc2 [nucleoplasm]
(Mus musculus)
Ascc2 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000305502
,
ENSP00000380877
,
ENSG00000100325
,
ENST00000542393
,
ENST00000307790
,
ENSP00000437570
,
ENST00000397771
OpenTargets
ENSG00000100325
GeneCards
ASCC2
HPA
ENSG00000100325-ASCC2
PRO
Q9H1I8
Pharos - Targets
Q9H1I8
GlyGen
Q9H1I8
PDB
6YXQ
,
2DI0
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
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