Fibroblast growth factor binding proteins (FGFBPs) are extracellular proteins that bind to FGFs and extract them from the extracellular matrix, thereby increasing their mitogenic potential (Wu et al, 1991; Tassi et al, 2001; Beer et al, 2005; reviewed in Abuharbeid et al, 2005). FGFBP1 has been shown to bind to FGF1, 2, 7, 10 and 22 by co-immunoprecipitation and/or competition assay (Tassi et al, 2001; Beer et al, 2005). Furthermore, it has been shown that stimulation of FGF7 along with FGFBP1 enhances the proliferation of FGFR2b-expressing cells (Beer et al, 2005). FGFBP expression is upregulated in some cancers and contributes to tumor growth and angiogenesis (reviewed in Abuharbeid et al, 2005).
Beer, HD, Bittner, M, Niklaus, G, Munding, C, Max, N, Goppelt, A, Werner, S
Abuharbeid, S, Czubayko, F
Wu, DQ, Kan, MK, Sato, GH, Okamoto, T, Sato, JD
Tassi, E, Al-Attar, A, Aigner, A, Swift, MR, McDonnell, K, Karavanov, A, Wellstein, A
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