Fibroblast growth factor binding proteins (FGFBPs) are extracellular proteins that bind to FGFs and extract them from the extracellular matrix, thereby increasing their mitogenic potential (Wu et al, 1991; Tassi et al, 2001; Beer et al, 2005; reviewed in Abuharbeid et al, 2005). FGFBP1 has been shown to bind to FGF1, 2, 7, 10 and 22 by co-immunoprecipitation and/or competition assay (Tassi et al, 2001; Beer et al, 2005). Furthermore, it has been shown that stimulation of FGF7 along with FGFBP1 enhances the proliferation of FGFR2b-expressing cells (Beer et al, 2005). FGFBP expression is upregulated in some cancers and contributes to tumor growth and angiogenesis (reviewed in Abuharbeid et al, 2005).
Czubayko, F, Abuharbeid, S
Beer, HD, Bittner, M, Max, N, Werner, S, Munding, C, Goppelt, A, Niklaus, G
Sato, GH, Sato, JD, Kan, MK, Okamoto, T, Wu, DQ
McDonnell, K, Swift, MR, Aigner, A, Tassi, E, Wellstein, A, Al-Attar, A, Karavanov, A
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