Reactome | FGFBPs bind FGFs

FGFBPs bind FGFs

Stable Identifier

R-HSA-5656070

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - FGFR2 ligand binding and activation (Homo sapiens)
        
        FGFR2b ligand binding and activation (Homo sapiens)
        
        FGFBPs bind FGFs (Homo sapiens)

General

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Fibroblast growth factor binding proteins (FGFBPs) are extracellular proteins that bind to FGFs and extract them from the extracellular matrix, thereby increasing their mitogenic potential (Wu et al, 1991; Tassi et al, 2001; Beer et al, 2005; reviewed in Abuharbeid et al, 2005). FGFBP1 has been shown to bind to FGF1, 2, 7, 10 and 22 by co-immunoprecipitation and/or competition assay (Tassi et al, 2001; Beer et al, 2005). Furthermore, it has been shown that stimulation of FGF7 along with FGFBP1 enhances the proliferation of FGFR2b-expressing cells (Beer et al, 2005). FGFBP expression is upregulated in some cancers and contributes to tumor growth and angiogenesis (reviewed in Abuharbeid et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
16324873	The fibroblast growth factor-binding protein FGF-BP Abuharbeid, S, Czubayko, F	Int J Biochem Cell Biol	2006
15806171	The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair Beer, HD, Bittner, M, Niklaus, G, Munding, C, Max, N, Goppelt, A, Werner, S	Oncogene	2005
1885605	Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors Wu, DQ, Kan, MK, Sato, GH, Okamoto, T, Sato, JD	J. Biol. Chem.	1991
11509569	Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein Tassi, E, Al-Attar, A, Aigner, A, Swift, MR, McDonnell, K, Karavanov, A, Wellstein, A	J. Biol. Chem.	2001