FGFBPs bind FGFs

Stable Identifier
R-HSA-5656070
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Fibroblast growth factor binding proteins (FGFBPs) are extracellular proteins that bind to FGFs and extract them from the extracellular matrix, thereby increasing their mitogenic potential (Wu et al, 1991; Tassi et al, 2001; Beer et al, 2005; reviewed in Abuharbeid et al, 2005). FGFBP1 has been shown to bind to FGF1, 2, 7, 10 and 22 by co-immunoprecipitation and/or competition assay (Tassi et al, 2001; Beer et al, 2005). Furthermore, it has been shown that stimulation of FGF7 along with FGFBP1 enhances the proliferation of FGFR2b-expressing cells (Beer et al, 2005). FGFBP expression is upregulated in some cancers and contributes to tumor growth and angiogenesis (reviewed in Abuharbeid et al, 2005).

Literature References
PubMed ID Title Journal Year
15806171 The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair

Beer, HD, Bittner, M, Niklaus, G, Munding, C, Max, N, Goppelt, A, Werner, S

Oncogene 2005
16324873 The fibroblast growth factor-binding protein FGF-BP

Abuharbeid, S, Czubayko, F

Int J Biochem Cell Biol 2006
1885605 Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors

Wu, DQ, Kan, MK, Sato, GH, Okamoto, T, Sato, JD

J. Biol. Chem. 1991
11509569 Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein

Tassi, E, Al-Attar, A, Aigner, A, Swift, MR, McDonnell, K, Karavanov, A, Wellstein, A

J. Biol. Chem. 2001
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