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POLK [nucleoplasm]
Stable Identifier
R-HSA-5655487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA polymerase kappa, DINB1, DINP
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
TRIM25 binds monoUb:164-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Translesion synthesis by POLK (Homo sapiens)
POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:POLH,POLK [nucleoplasm] (Homo sapiens)
POLH,POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
POLK [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBT6 POLK
Gene Names
POLK, DINB1
Chain
chain:1-870
Reference Genes
BioGPS Gene:51426 POLK
COSMIC (genes):POLK POLK
CTD Gene:51426 POLK
dbSNP Gene:51426 POLK
ENSEMBL:ENSG00000122008 POLK
HGNC:9183 POLK
KEGG:hsa:51426 POLK
Monarch:51426 POLK
NCBI Gene:51426 POLK
OMIM:605650 POLK
UCSC:Q9UBT6 POLK
Reference Transcript
RefSeq:XM_017009563.1 POLK
RefSeq:NM_001345922.1 POLK
RefSeq:XM_017009559.1 POLK
RefSeq:NM_016218.3 POLK
RefSeq:XM_017009560.1 POLK
Other Identifiers
11729678_a_at
11747254_a_at
11755428_a_at
11757974_s_at
11760947_at
1555317_3p_at
1555317_PM_at
1555317_at
16986283
16986314
223260_PM_s_at
223260_s_at
223261_PM_at
223261_at
2816029
2816031
2816032
2816038
2816042
2816045
2816050
2816051
2816052
2816054
2816055
2816056
2816057
2816058
2816059
2816061
2816062
2816063
2816066
2816067
2816070
2816071
2816072
2816073
2816074
2816075
2816076
2816077
2816078
2816079
2816080
2816081
2816082
2816083
2816084
2816085
2816086
2816088
2816090
2816092
51426
56673_at
58997_r_at
70382_at
78928_i_at
78930_r_at
78932_at
8106303
A_14_P104795
A_14_P129899
A_19_P00805145
A_21_P0004266
A_23_P386450
A_24_P303160
A_24_P919863
A_24_P923478
GE498692
GE62095
GE79867
GO:0003677
GO:0003684
GO:0003824
GO:0003887
GO:0005634
GO:0005654
GO:0006259
GO:0006260
GO:0006281
GO:0006297
GO:0006974
GO:0016604
GO:0016740
GO:0034644
GO:0042276
GO:0043226
GO:0046872
GO:0071897
GO:0090734
GO:0140097
HMNXSV003004809
HMNXSV003022040
HMNXSV003052904
Hs2.135756.2.S1_3p_at
Hs2.135756.2.S1_3p_x_at
ILMN_1703474
PH_hs_0017840
PH_hs_0027848
TC05000364.hg
TC05002455.hg
g6463739_3p_a_at
g6681759_3p_at
p23002
Participates
as a member of
DNA polymerase Y [nucleoplasm] (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
as a component of
POLK:Mg2+,Mn2+ [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Homo sapiens)
as a candidate of
POLH,POLK [nucleoplasm] (Homo sapiens)
Inferred To
Polk [nucleoplasm]
(Rattus norvegicus)
DINB1 [nucleoplasm]
(Gallus gallus)
Ghost homologue of POLK [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of POLK [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of POLK [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of POLK [nucleoplasm]
(Xenopus tropicalis)
POLK [nucleoplasm]
(Bos taurus)
POLK [nucleoplasm]
(Caenorhabditis elegans)
POLK [nucleoplasm]
(Canis familiaris)
POLK [nucleoplasm]
(Dictyostelium discoideum)
POLK [nucleoplasm]
(Mus musculus)
POLK [nucleoplasm]
(Schizosaccharomyces pombe)
POLK [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_016865048.1
,
XP_016865049.1
,
NP_057302.1
,
XP_016865052.1
,
NP_001332851.1
OpenTargets
ENSG00000122008
ENSEMBL
ENST00000515295
,
ENST00000510815
,
ENST00000504026
,
ENST00000509126
,
ENSP00000423532
,
ENSG00000122008
,
ENSP00000426853
,
ENSP00000425075
,
ENST00000508526
,
ENST00000241436
,
ENSP00000424174
,
ENSP00000241436
,
ENSP00000422094
ZINC - Substances
POLK_HUMAN
ZINC target
Q9UBT6
PRO
Q9UBT6
GlyGen
Q9UBT6
PDB
3PZP
,
4U7C
,
2W7O
,
5W2C
,
6CST
,
4U6P
,
6BRX
,
4BA9
,
6BS1
,
5W2A
,
2OH2
,
5T14
,
2LSI
,
7NV1
,
7NV0
,
2W7P
,
3IN5
,
1T94
,
4GK5
IntEnz
2.7.7.7
HPA
ENSG00000122008-POLK
GeneCards
POLK
Pharos - Targets
Q9UBT6
ZINC - Predictions - Purchasable
POLK_HUMAN
HMDB Protein
HMDBP00965
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