Reactome | USP1 autocleavage

USP1 autocleavage

Stable Identifier

R-HSA-5655483

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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UV radiation, through an unknown mechanism, triggers USP1 autocleavage immediately after a conserved Gly-Gly motif. The products of USP1 autocleavage are targeted for proteasome-mediated degradation, thus preventing the activity of USP1:WDR48 (USP1:UAF1) deubiquitinase complex and allowing for monoubiquitinated PCNA to accumulate and stimulate translesion DNA synthesis (TLS) (Huang et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16531995	Regulation of monoubiquitinated PCNA by DUB autocleavage Ploegh, HL, Galardy, PJ, Haas, W, Cohn, MA, Nijman, SM, Gygi, SP, Huang, TT, Bernards, R, Mirchandani, KD, D'Andrea, AD	Nat. Cell Biol.	2006