USP1 autocleavage

Stable Identifier
R-HSA-5655483
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

UV radiation, through an unknown mechanism, triggers USP1 autocleavage immediately after a conserved Gly-Gly motif. The products of USP1 autocleavage are targeted for proteasome-mediated degradation, thus preventing the activity of USP1:WDR48 (USP1:UAF1) deubiquitinase complex and allowing for monoubiquitinated PCNA to accumulate and stimulate translesion DNA synthesis (TLS) (Huang et al. 2006).

Literature References
PubMed ID Title Journal Year
16531995 Regulation of monoubiquitinated PCNA by DUB autocleavage

Huang, TT, Nijman, SM, Mirchandani, KD, Galardy, PJ, Cohn, MA, Haas, W, Gygi, SP, Ploegh, HL, Bernards, R, D'Andrea, AD

Nat. Cell Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptidase activity of USP1:WDR48 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created