USP1:WDR48 deubiquitinates monoUb:K164-PCNA

Stable Identifier
R-HSA-5655466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Deubiquitinating enzyme USP1, bound to its accessory protein WDR48 (UAF1), deubiquitinates PCNA (MonoUb:K164-PCNA), thus preventing excessive activation of DNA translesion synthesis (TLS) (Huang et al. 2006).

Literature References
PubMed ID Title Journal Year
16531995 Regulation of monoubiquitinated PCNA by DUB autocleavage

Huang, TT, Nijman, SM, Mirchandani, KD, Galardy, PJ, Cohn, MA, Haas, W, Gygi, SP, Ploegh, HL, Bernards, R, D'Andrea, AD

Nat. Cell Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created