USP1:WDR48 deubiquitinates monoUb:K164-PCNA

Stable Identifier
R-HSA-5655466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP1:WDR48 deubiquitinates monoUb:K164-PCNA
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Deubiquitinating enzyme USP1, bound to its accessory protein WDR48 (UAF1), deubiquitinates PCNA (MonoUb:K164-PCNA), thus preventing excessive activation of DNA translesion synthesis (TLS) (Huang et al. 2006).
Literature References
PubMed ID Title Journal Year
16531995 Regulation of monoubiquitinated PCNA by DUB autocleavage

Ploegh, HL, Galardy, PJ, Haas, W, Cohn, MA, Nijman, SM, Gygi, SP, Huang, TT, Bernards, R, Mirchandani, KD, D'Andrea, AD

Nat. Cell Biol. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm]

Physical Entity
MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Rattus norvegicus)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Schizosaccharomyces pombe)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-12-05)
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