USP1:WDR48 deubiquitinates monoUb:K164-PCNA

Stable Identifier
R-HSA-5655466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Deubiquitinating enzyme USP1, bound to its accessory protein WDR48 (UAF1), deubiquitinates PCNA (MonoUb:K164-PCNA), thus preventing excessive activation of DNA translesion synthesis (TLS) (Huang et al. 2006).
Literature References
PubMed ID Title Journal Year
16531995 Regulation of monoubiquitinated PCNA by DUB autocleavage

Ploegh, HL, Galardy, PJ, Haas, W, Cohn, MA, Nijman, SM, Gygi, SP, Huang, TT, Bernards, R, Mirchandani, KD, D'Andrea, AD

Nat. Cell Biol. 2006
Participants
Participates
Catalyst Activity

cysteine-type deubiquitinase activity of MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm]

Orthologous Events
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