Activated FGFR4 mutants phosphorylate PLCG1

Stable Identifier
R-HSA-5655341
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activated FGFR4 mutants phosphorylate PLCG1
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By analogy with the wild-type pathway, PLC-gamma is presumed to be phosphorylated by activated FGFR mutants, resulting in PLC-gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3.
Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR4 mutants:PLCG1 [plasma membrane]

Physical Entity
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
Functional status

Gain of function of Activated FGFR4 mutants:PLCG1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
bone development disease DOID:0080006
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2014-12-05)
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