p-4Y-PLCG1 dissociates from activated FGFR3 mutants

Stable Identifier
R-HSA-5655247
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
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p-4Y-PLCG1 dissociates from activated FGFR3 mutants
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Dissociation from the activated receptor quickly follows phosphorylation of PLC-gamma. Phosphorylated PLC-gamma catalyzes the hydrolysis of phosphatidylinositol(4, 5)bisphosphate to generate two second messengers, diacylglycerol and inositol (1,4,5) triphosphate.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
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Normal reaction
p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)
Functional status

Gain of function of Activated FGFR3 mutants:p-4Y-PLCG1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
bone development disease DOID:0080006
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2014-12-05)
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