Activated FGFR3 mutants phosphorylate PLCG1

Stable Identifier
R-HSA-5655243
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activated FGFR3 mutants phosphorylate PLCG1
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By analogy with the wild-type pathway, PLC-gamma is presumed to be phosphorylated by activated FGFR mutants, resulting in PLC-gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated FGFR3 mutants: PLCG1 [plasma membrane]
Physical Entity
Activated FGFR3 mutants: PLCG1 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Normal reaction
Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)
Disease
Name Identifier Synonyms
bone development disease 0080006
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2014-12-05)
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