Activated FGFR3 point and translocation mutants phosphorylate PLCG1

Stable Identifier
R-HSA-5655243
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated FGFR3 point and translocation mutants phosphorylate PLCG1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

By analogy with the wild-type pathway, PLC-gamma is presumed to be phosphorylated by activated FGFR mutants, resulting in PLC-gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane]

Physical Entity
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)
Functional status

Gain of function of Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
bone development disease DOID:0080006
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2014-12-05)
Cite Us!