Reactome | SPRTN binds monoUb:K164-PCNA associated with POLH

SPRTN binds monoUb:K164-PCNA associated with POLH

Stable Identifier

R-HSA-5654986

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SPRTN binds monoUb:K164-PCNA associated with POLH

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SPRTN (Spartan, C1orf124, DVC1) contains a PIP box and a UBZ domain that both participate in binding to monoubiquitinated PCNA (MonoUb:K164-PCNA), thus regulating POLH-mediated translesion DNA synthesis (TLS). The SPRTN UBZ domain may also interact with other monoubiquitinated proteins at the site of DNA damage. SPRTN can also bind RAD18 and function in a positive feedback loop to increase (or maintain) PCNA monoubiquitination (Centore et al. 2012, Ghosal et al. 2012).

Endogenous SPRTN is predominantly expressed during S and G2 phases of the cell cycle, and is rapidly degraded by the APC:CDH1 complex at mitotic exit (Mosbech et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22681887	Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response Centore, RC, Yazinski, SA, Tse, A, Zou, L	Mol. Cell	2012
23042605	DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks Mosbech, A, Gibbs-Seymour, I, Kagias, K, Thorslund, T, Beli, P, Povlsen, L, Nielsen, SV, Smedegaard, S, Sedgwick, G, Lukas, C, Hartmann-Petersen, R, Lukas, J, Choudhary, C, Pocock, R, Bekker-Jensen, S, Mailand, N	Nat. Struct. Mol. Biol.	2012
22902628	Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis Ghosal, G, Leung, JW, Nair, BC, Fong, KW, Chen, J	J. Biol. Chem.	2012