FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-5654714
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).
Literature References
PubMed ID Title Journal Year
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR

Proc Natl Acad Sci U S A 2001
15863030 Cellular signaling by fibroblast growth factor receptors

Schlessinger, J, Eswarakumar, VP, Lax, I

Cytokine Growth Factor Rev 2005
Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]

Orthologous Events
Cross References
Rhea
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