Reactome | FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier

R-HSA-5654714

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Downstream signaling of activated FGFR4 (Homo sapiens)
        
        PI-3K cascade:FGFR4 (Homo sapiens)
        
        FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).

Literature References

PubMed ID	Title	Journal	Year
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR	Proc Natl Acad Sci U S A	2001
15863030	Cellular signaling by fibroblast growth factor receptors Schlessinger, J, Eswarakumar, VP, Lax, I	Cytokine Growth Factor Rev	2005