FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-5654709
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once recruited to the membrane, PI3K catalyzes the phosphorylation of PI(4,5)P2 to PI(3,4,5)P3.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]

Physical Entity
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Cross References
Rhea
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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