Reactome | FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3

FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier

R-HSA-5654697

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        PI-3K cascade:FGFR2 (Homo sapiens)
        
        FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)

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FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3

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Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).

Literature References

PubMed ID	Title	Journal	Year
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I	Proc Natl Acad Sci U S A	2001
15863030	Cellular signaling by fibroblast growth factor receptors Eswarakumar, VP, Lax, I, Schlessinger, J	Cytokine Growth Factor Rev	2005