Activated FGFR4:p-FRS bind to PPTN11

Stable Identifier
R-HSA-5654658
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.
Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR

Mol Cell Biol 1998
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ

Oncogene 2003
Participants
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Orthologous Events
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