Activated FGFR4:p-FRS bind to PPTN11

Stable Identifier
R-HSA-5654658
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated FGFR4:p-FRS bind to PPTN11
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.
Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR

Mol Cell Biol 1998
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ

Oncogene 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)
Activated FGFR4:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)
Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
Cite Us!