Activated FGFR3:p-SHC1 binds GRB2:SOS1

Stable Identifier
R-HSA-5654646
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Activated FGFR3:p-SHC1 binds GRB2:SOS1
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Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway.

Literature References
PubMed ID Title Journal Year
9480847 Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells

Frankel, P, Foster, DA, Curto, M, Carrero, A

Biochem Biophys Res Commun 1998
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M

J Biol Chem 1997
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Kanda, S, Klint, P, Claesson-Welsh, L

J Biol Chem 1995
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Orthologous Events
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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