Reactome | Activated FGFR3:p-SHC1 binds GRB2:SOS1

Activated FGFR3:p-SHC1 binds GRB2:SOS1

Stable Identifier

R-HSA-5654646

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR3 (Homo sapiens)
      - Downstream signaling of activated FGFR3 (Homo sapiens)
        
        SHC-mediated cascade:FGFR3 (Homo sapiens)
        
        Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)

General

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Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway.

Literature References

PubMed ID	Title	Journal	Year
9480847	Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells Curto, M, Frankel, P, Carrero, A, Foster, DA	Biochem Biophys Res Commun	1998
7559490	Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells Klint, P, Kanda, S, Claesson-Welsh, L	J Biol Chem	1995
9045692	Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK	J Biol Chem	1997