Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway.
Frankel, P, Foster, DA, Curto, M, Carrero, A
Kanda, S, Klint, P, Claesson-Welsh, L
Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M
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