Reactome | Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Stable Identifier

R-HSA-5654620

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        PI-3K cascade:FGFR2 (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)

General

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Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

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p-PPTN11 recruits GRB2-GAB1 to the activated receptor.

Literature References

PubMed ID	Title	Journal	Year
9632781	Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR	Mol Cell Biol	1998
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR	Proc Natl Acad Sci U S A	2001
9299490	SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells Lim, YP, Low, BC, Ong, SH, Guy, GR	Biochem Biophys Res Commun	1997
9045692	Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M	J Biol Chem	1997