Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Stable Identifier
R-HSA-5654620
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p-PPTN11 recruits GRB2-GAB1 to the activated receptor.

Literature References
PubMed ID Title Journal Year
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2001
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
9299490 SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells

Ong, SH, Lim, YP, Low, BC, Guy, GR

Biochem Biophys Res Commun 1997
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK

J Biol Chem 1997
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created