Reactome | Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1

Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1

Stable Identifier

R-HSA-5654612

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        PI-3K cascade:FGFR2 (Homo sapiens)
        
        Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)

General

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Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The direct GRB2-binding sites of FRS2 have a major role in activation of the PI3K pathway.

Literature References

PubMed ID	Title	Journal	Year
9632781	Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J	Mol Cell Biol	1998
9182757	A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J	Cell	1997
14534538	The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 Agazie, YM, Movilla, N, Ischenko, I, Hayman, MJ	Oncogene	2003
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I	Proc Natl Acad Sci U S A	2001