Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1

Stable Identifier
R-HSA-5654612
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
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The direct GRB2-binding sites of FRS2 have a major role in activation of the PI3K pathway.

Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D

Cell 1997
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR

Mol Cell Biol 1998
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ

Oncogene 2003
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR

Proc Natl Acad Sci U S A 2001
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Orthologous Events
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-03)
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