Activated FGFR2:p-FRS bind to PPTN11

Stable Identifier
R-HSA-5654608
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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 | PPTX  | SBGN
Activated FGFR2:p-FRS bind to PPTN11
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.
Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Agazie, YM, Movilla, N, Ischenko, I, Hayman, MJ

Oncogene 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR2:p-FRS bind to PPTN11 (Mus musculus)
Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR2:p-FRS bind to PPTN11 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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