Activated FGFR2 phosphorylates FRS3

Stable Identifier
R-HSA-5654605
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Activated FGFR2 phosphorylates FRS3
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FRS3 (also known as FRS2 beta) is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. By sequence comparison, FRS3 has the 2 PPTN11/SHP2-binding sites and has three of the four GRB2-binding sites.

Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
12419216 The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

Lax, I, Wong, A, Lamothe, B, Lee, A, Frost, A, Hawes, J, Schlessinger, J

Mol Cell 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated FGFR2:FRS3 [plasma membrane]
Physical Entity
Activated FGFR2:FRS3 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Activated FGFR2 phosphorylates FRS3 (Canis familiaris)
Activated FGFR2 phosphorylates FRS3 (Danio rerio)
Activated FGFR2 phosphorylates FRS3 (Drosophila melanogaster)
Activated FGFR2 phosphorylates FRS3 (Mus musculus)
Activated FGFR2 phosphorylates FRS3 (Rattus norvegicus)
Activated FGFR2 phosphorylates FRS3 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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