Activated FGFR2 phosphorylates FRS3

Stable Identifier
R-HSA-5654605
Type
Reaction
Species
Homo sapiens
Compartment
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FRS3 (also known as FRS2 beta) is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. By sequence comparison, FRS3 has the 2 PPTN11/SHP2-binding sites and has three of the four GRB2-binding sites.

Literature References
PubMed ID Title Journal Year
12419216 The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

Frost, A, Wong, A, Hawes, J, Lee, A, Lamothe, B, Schlessinger, J, Lax, I

Mol Cell 2002
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D

Cell 1997
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR2:FRS3 [plasma membrane]

Orthologous Events
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