FRS3 (also known as FRS2 beta) is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. By sequence comparison, FRS3 has the 2 PPTN11/SHP2-binding sites and has three of the four GRB2-binding sites.
Frost, A, Wong, A, Hawes, J, Lee, A, Lamothe, B, Schlessinger, J, Lax, I
Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D
protein tyrosine kinase activity of Activated FGFR2:FRS3 [plasma membrane]
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