Reactome | Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Stable Identifier

R-HSA-5654600

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - Downstream signaling of activated FGFR1 (Homo sapiens)
        
        SHC-mediated cascade:FGFR1 (Homo sapiens)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.

Literature References

PubMed ID	Title	Journal	Year
8493579	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L	Science	1993