Reactome | Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Stable Identifier

R-HSA-5654594

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - Downstream signaling of activated FGFR1 (Homo sapiens)
        
        PI-3K cascade:FGFR1 (Homo sapiens)
        
        Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)

General

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Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

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p-PPTN11 recruits GRB2-GAB1 to the activated receptor.

Literature References

PubMed ID	Title	Journal	Year
9632781	Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J	Mol Cell Biol	1998
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I	Proc Natl Acad Sci U S A	2001
9299490	SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells Ong, SH, Lim, YP, Low, BC, Guy, GR	Biochem Biophys Res Commun	1997
9045692	Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK	J Biol Chem	1997