Reactome | Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1

Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1

Stable Identifier

R-HSA-5654592

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - Downstream signaling of activated FGFR1 (Homo sapiens)
        
        PI-3K cascade:FGFR1 (Homo sapiens)
        
        Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)

General

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Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1

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The direct GRB2-binding sites of FRS2 have a major role in activation of the PI3K pathway.

Literature References

PubMed ID	Title	Journal	Year
9182757	A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D	Cell	1997
9632781	Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR	Mol Cell Biol	1998
14534538	The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ	Oncogene	2003
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR	Proc Natl Acad Sci U S A	2001