Activated FGFR1 binds SHC1

Stable Identifier
R-HSA-5654573
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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Activated FGFR1 binds SHC1
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Although a role for SHC1 in FGF signalling has been implicated in many studies, it is not clear that SHC1 interacts directly with the receptor.

Literature References
PubMed ID Title Journal Year
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Klint, P, Kanda, S, Claesson-Welsh, L

J Biol Chem 1995
9480847 Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells

Curto, M, Frankel, P, Carrero, A, Foster, DA

Biochem Biophys Res Commun 1998
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK

J Biol Chem 1997
18840094 Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)

Schüller, AC, Ahmed, Z, Levitt, JA, Suen, KM, Suhling, K, Ladbury, JE

Biochem J 2008
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Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)