Activated FGFR4 binds SHC1

Stable Identifier
R-HSA-5654425
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated FGFR4 binds SHC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Although a role for SHC1 in FGF signalling has been implicated in many studies, it is not clear that SHC1 interacts directly with the receptor.
Literature References
PubMed ID Title Journal Year
9480847 Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells

Frankel, P, Foster, DA, Curto, M, Carrero, A

Biochem Biophys Res Commun 1998
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Kanda, S, Klint, P, Claesson-Welsh, L

J Biol Chem 1995
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M

J Biol Chem 1997
18840094 Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)

Suhling, K, Levitt, JA, Ladbury, JE, Suen, KM, Ahmed, Z, Schüller, AC

Biochem J 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
Activated FGFR4 binds SHC1 (Bos taurus)
Activated FGFR4 binds SHC1 (Canis familiaris)
Activated FGFR4 binds SHC1 (Drosophila melanogaster)
Activated FGFR4 binds SHC1 (Gallus gallus)
Activated FGFR4 binds SHC1 (Mus musculus)
Activated FGFR4 binds SHC1 (Rattus norvegicus)
Activated FGFR4 binds SHC1 (Sus scrofa)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
Cite Us!