Activated FGFR4:p-SHC1 binds GRB2:SOS1

Stable Identifier
Reaction [binding]
Homo sapiens
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Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway.

Literature References
PubMed ID Title Journal Year
9480847 Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells

Frankel, P, Foster, DA, Curto, M, Carrero, A

Biochem Biophys Res Commun 1998
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Kanda, S, Klint, P, Claesson-Welsh, L

J Biol Chem 1995
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M

J Biol Chem 1997
Orthologous Events
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