Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:PPTN11.
Klint, P, Kanda, S, Claesson-Welsh, L
Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J
Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I
Hadari, YR, Gotoh, N, Kouhara, H, Lax, I, Schlessinger, J
Ong, SH, Goh, KC, Lim, YP, Low, BC, Klint, P, Claesson-Welsh, L, Cao, X, Tan, YH, Guy, GR
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