FRS2 (also known as FRS alpha is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. FRS2 contains four binding sites for the adaptor protein GRB2 at residues Y196, Y306, Y349 and Y392, and two binding sites for the protein tyrosine phosphatase PPTN11/SHP2 at residues Y436 and Y471. Different FGFR isoforms may generate different phosphorylation patterns on FRS2 leading to alternate downstream signaling.
Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D
Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR
Goh, KC, Lim, YP, Klint, P, Tan, YH, Low, BC, Ong, SH, Cao, X, Claesson-Welsh, L, Guy, GR
protein tyrosine kinase activity of Activated FGFR3:FRS2 [plasma membrane]
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