Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange

Stable Identifier
R-HSA-5654392
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
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SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D

Science 1993
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Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane]

Physical Entity
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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