SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.
Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D
guanyl-nucleotide exchange factor activity of Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane]
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