Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
Stable Identifier
R-HSA-5654362
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11997436
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
Wong, A
,
Lee, A
,
Lamothe, B
,
Schlessinger, J
,
Lax, I
Proc Natl Acad Sci U S A
2002
Participants
components
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
(Homo sapiens)
Ub [cytosol]
(Homo sapiens)
Participates
as an output of
CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)
Inferred To
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Bos taurus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Canis familiaris)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Drosophila melanogaster)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Gallus gallus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Mus musculus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Rattus norvegicus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(Sus scrofa)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text