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Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
Stable Identifier
R-HSA-5654357
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11997436
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
Wong, A
,
Lee, A
,
Lamothe, B
,
Schlessinger, J
,
Lax, I
Proc Natl Acad Sci U S A
2002
Participants
components
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
(Homo sapiens)
Ub [cytosol]
(Homo sapiens)
Participates
as an output of
CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)
Inferred To
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Bos taurus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Canis familiaris)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Drosophila melanogaster)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Gallus gallus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Mus musculus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Rattus norvegicus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Sus scrofa)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
(Xenopus tropicalis)
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