Activated FGFR3 phosphorylates PLCG1

Stable Identifier
R-HSA-5654222
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated FGFR3 phosphorylates PLCG1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PLC gamma is phosphorylated by activated FGFR, resulting in PLC gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3. Tyrosine phosphorylation of PLCgamma by FGFR4 is weaker than that seen by other isoforms of FGFR.
Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of activated FGFR3:PLCG1 [plasma membrane]

Physical Entity
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)
Activated FGFR3 phosphorylates PLCG1 (Danio rerio)
Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)
Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)
Activated FGFR3 phosphorylates PLCG1 (Mus musculus)
Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Created
Rothfels, K  (2014-12-04)
Cite Us!