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Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
Stable Identifier
R-HSA-5654195
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
PI-3K cascade:FGFR3 (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Participants
components
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
(Homo sapiens)
PIK3CA [cytosol]
(Homo sapiens)
Participates
as an output of
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
as a member of
Activator:PI3K [plasma membrane] (Homo sapiens)
Inferred To
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Gallus gallus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Mus musculus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Sus scrofa)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(Xenopus tropicalis)
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