p-4Y-PLCG1 dissociates from activated FGFR2

Stable Identifier
R-HSA-5654157
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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p-4Y-PLCG1 dissociates from activated FGFR2
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Dissociation from the activated receptor quickly follows phosphorylation of PLC-gamma. Phosphorylated PLC-gamma catalyzes the hydrolysis of phosphatidylinositol(4, 5)bisphosphate to generate two second messengers, diacylglycerol and inositol (1,4,5) triphosphate.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
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Orthologous Events
p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Caenorhabditis elegans)
p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR2 (Danio rerio)
p-4Y-PLCG1 dissociates from activated FGFR2 (Drosophila melanogaster)
p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Created
Rothfels, K  (2014-12-03)