Reactome | p-4Y-PLCG1 dissociates from activated FGFR2

p-4Y-PLCG1 dissociates from activated FGFR2

Stable Identifier

R-HSA-5654157

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        Phospholipase C-mediated cascade; FGFR2 (Homo sapiens)
        
        p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)

General

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p-4Y-PLCG1 dissociates from activated FGFR2

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Dissociation from the activated receptor quickly follows phosphorylation of PLC-gamma. Phosphorylated PLC-gamma catalyzes the hydrolysis of phosphatidylinositol(4, 5)bisphosphate to generate two second messengers, diacylglycerol and inositol (1,4,5) triphosphate.

Literature References