p-4Y-PLCG1 dissociates from activated FGFR2

Stable Identifier
R-HSA-5654157
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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p-4Y-PLCG1 dissociates from activated FGFR2
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Dissociation from the activated receptor quickly follows phosphorylation of PLC-gamma. Phosphorylated PLC-gamma catalyzes the hydrolysis of phosphatidylinositol(4, 5)bisphosphate to generate two second messengers, diacylglycerol and inositol (1,4,5) triphosphate.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
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Orthologous Events
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p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-06)
Created
Rothfels, K  (2014-12-03)
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